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Gene

SLFN14

schlafen family member 14

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 35,543,985–35,560,819 (GRCh38)
Exons
6 exons across 16.8 kb
Protein
912 amino acids
MANE Select transcript
ENST00000674182.1NM_001129820.2
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      Actionability

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How SLFN14 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where SLFN14 sits. SLFN14 and 28 genes near it on chromosome 17, from 35,052,402 to 36,052,401.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.335.2 Mb35.4 Mb35.6 Mb35.8 Mb36 MbRFFL: 35,005,990–35,089,899, reverse strandRFFL: 35,011,349–35,121,493, reverse strandRAD51D: 35,092,221–35,121,522, reverse strandRAD51DFNDC8: 35,121,615–35,130,732, forward strandFNDC8NLE1: 35,125,556–35,142,313, reverse strandNLE1UNC45B: 35,146,495–35,189,346, forward strandUNC45BSLC35G3: 35,192,520–35,194,393, reverse strandSLC35G3SLFN5: 35,243,043–35,273,655, forward strandSLFN5SLFN11: 35,350,305–35,373,701, reverse strandSLFN11SLFN12: 35,409,339–35,433,475, reverse strandSLFN12SLFN13: 35,435,096–35,449,766, reverse strandSLFN13SLFN12L: 35,464,249–35,537,770, reverse strandSLFN12LSLFN14: 35,543,985–35,560,819, reverse strandSLFN14PEX12: 35,574,795–35,578,863, reverse strandPEX12AP2B1: 35,578,046–35,726,417, forward strandAP2B1RASL10B: 35,731,639–35,743,521, forward strandRASL10BGAS2L2: 35,744,511–35,753,260, reverse strandGAS2L2MMP28: 35,756,249–35,795,719, reverse strandMMP28PGBDF: 35,760,887–35,765,079, forward strandPGBDFTAF15: 35,809,475–35,864,615, forward strandTAF15HEATR9: 35,854,946–35,868,891, reverse strandHEATR9CCL5: 35,871,491–35,880,793, reverse strandCCL5RDM1: 35,918,066–35,930,794, reverse strandRDM1LYZL6: 35,934,518–35,943,713, reverse strandLYZL6CCL16: 35,976,192–35,981,580, reverse strandCCL16CCL14: 35,983,288–35,987,033, reverse strandCCL14CCL15-CCL14: 35,983,656–36,001,621, reverse strandCCL15-CCL14CCL15: 35,988,463–36,002,119, reverse strandCCL15CCL23: 36,013,056–36,017,979, reverse strandDiagram of SLFN14: 6 exons on the reverse strand of chromosome 17Exon 5: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 6: 35,543,985–35,549,073, 5,089 basesExon 5: 35,552,730–35,553,444, 715 basesExon 4: 35,554,576–35,554,704, 129 basesExon 3: 35,557,003–35,558,106, 1,104 basesExon 2: 35,559,727–35,559,805, 79 basesExon 1: 35,560,767–35,560,819, 53 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 16.8 kb; 2,739 of those bases code for the protein.

Sequencing SLFN14

1Low

How hard SLFN14 is to sequence with short reads, out of 100

  • Mappability1.2%
  • Homology0%
  • Repeats1.8%
  • GC content3.2%
  • Reference coverage0%

2

positions in SLFN14 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.8 kb of SLFN14, introns included, not only the 7.2 kb of exons.

Genes linked to the same conditions

Traits linked to SLFN14

The Human Phenotype Ontology lists these as features of the rare conditions SLFN14 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). SLFN14 gene: schlafen family member 14. Retrieved 17 October 2026, from https://dantelabs.com/genes/slfn14

Vancouver

Dante Labs. SLFN14 gene: schlafen family member 14 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slfn14

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