Gene
PRDX3
peroxiredoxin 3
- HGNC 9354(opens in a new tab)
- Ensembl gene ENSG00000165672(opens in a new tab)
- NCBI Gene 10935(opens in a new tab)
Summary
- Cytogenetic location
- 10q26.11
- Coordinates
- Chromosome 10: 119,167,720–119,178,812 (GRCh38)
- Exons
- 7 exons across 11.1 kb
- Protein
- 256 amino acids
- Inheritance
- Autosomal recessive
- Also known as
- MER5, AOP-1, SP-22
- Previous symbols
- AOP1
- MANE Select transcript
- ENST00000298510.4NM_006793.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Hereditary Corneal Dystrophies
- Corneal Dystrophy
A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.
Broader groupings
Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)
- Autosomal Recessive Cerebellar AtaxiaAutosomal recessive
One of 57 genes linked to it
A group of recessively inherited ataxias caused by biallelic variants in genes such as RFC1, FXN, SACS, TTPA, SETX, APTX, PNKP, ANO10 and SYNE1.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Ataxia with vitamin E deficiency (TTPA) is treatable with vitamin E supplements; other forms are managed with physiotherapy and symptom care, and relatives can be offered carrier testing.
Inheritance
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How PRDX3 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.6 kb of the gene's 11.1 kb; 771 of those bases code for the protein.
How a genome test reads PRDX3
3
positions in PRDX3 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 11.1 kb of PRDX3, introns included, not only the 1.6 kb of exons.
Traits linked to PRDX3
The Human Phenotype Ontology lists these as features of the rare conditions PRDX3 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). PRDX3 gene: peroxiredoxin 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/prdx3
Dante Labs. PRDX3 gene: peroxiredoxin 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prdx3
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