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Gene

TACSTD2

tumor associated calcium signal transducer 2

Summary

Cytogenetic location
1p32.1
Coordinates
Chromosome 1: 58,575,433–58,577,252 (GRCh38)
Exons
1 exon across 1.8 kb
Protein
323 amino acids
Also known as
TROP2, GA733-1, EGP-1
Previous symbols
M1S1
MANE Select transcript
ENST00000371225.4NM_002353.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Corneal Dystrophies

    • Corneal Dystrophy

      A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.

How TACSTD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where TACSTD2 sits. TACSTD2 and 4 genes near it on chromosome 1, from 58,076,343 to 59,076,342.Chromosome 11p32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4458.2 Mb58.4 Mb58.6 Mb58.8 Mb59 MbDAB1: 56,994,778–58,546,734, reverse strandDAB1OMA1: 58,415,384–58,546,838, reverse strandOMA1TACSTD2: 58,575,433–58,577,252, reverse strandTACSTD2MYSM1: 58,643,440–58,700,108, reverse strandMYSM1JUN: 58,776,845–58,784,048, reverse strandJUNDiagram of TACSTD2: one exon on the reverse strand of chromosome 1Exon 1: 2 known disease-causing sitesExon 1: 58,575,433–58,577,252, 1,820 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 1.8 kb; 972 of those bases code for the protein.

How a genome test reads TACSTD2

2

positions in TACSTD2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.8 kb of TACSTD2, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TACSTD2 gene: tumor associated calcium signal transducer 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tacstd2

Vancouver

Dante Labs. TACSTD2 gene: tumor associated calcium signal transducer 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tacstd2

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