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Gene

KRT12

keratin 12

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 40,861,303–40,867,223 (GRCh38)
Exons
8 exons across 5.9 kb
Protein
494 amino acids
Also known as
K12
MANE Select transcript
ENST00000251643.5NM_000223.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Corneal Dystrophies

    • Corneal Dystrophy

      A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.

How KRT12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 17, with a bracket where KRT12 sits. KRT12 and 54 genes near it on chromosome 17, from 40,364,263 to 41,364,262.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.340.4 Mb40.6 Mb40.8 Mb41 Mb41.2 MbGJD3: 40,360,652–40,364,737, reverse strandGJD3TOP2A: 40,388,521–40,417,941, reverse strandTOP2AIGFBP4: 40,442,913–40,460,822, forward strandIGFBP4TNS4: 40,475,828–40,501,630, reverse strandTNS4CCR7: 40,551,081–40,565,478, reverse strandCCR7SMARCE1: 40,624,962–40,648,667, reverse strandSMARCE1: 40,627,356–40,665,141, reverse strandKRT222: 40,654,665–40,665,181, reverse strandKRT222KRT24: 40,697,991–40,703,758, reverse strandKRT24KRT25: 40,748,021–40,755,331, reverse strandKRT25KRT26: 40,766,238–40,772,201, reverse strandKRT26KRT27: 40,776,808–40,782,550, reverse strandKRT27KRT28: 40,792,196–40,799,959, reverse strandKRT28KRT10: 40,817,784–40,822,614, reverse strandKRT10KRT12: 40,861,303–40,867,223, reverse strandKRT12KRT20: 40,872,785–40,885,249, reverse strandKRT20KRT23: 40,922,696–40,937,646, reverse strandKRT23KRT39: 40,958,392–40,966,948, reverse strandKRT39KRT40: 40,977,715–40,987,135, reverse strandKRT40KRTAP3-3: 40,993,430–40,994,164, reverse strandKRTAP3-3KRTAP3-2: 40,999,193–40,999,906, reverse strandKRTAP3-2KRTAP3-1: 41,008,521–41,019,324, reverse strandKRTAP1-5: 41,026,026–41,027,208, reverse strandKRTAP1-4: 41,029,351–41,030,195, reverse strandKRTAP1-3: 41,033,884–41,034,874, reverse strandKRTAP1-1: 41,040,541–41,041,450, reverse strandKRTAP2-1: 41,046,541–41,047,316, reverse strandKRTAP2-2: 41,054,498–41,055,230, reverse strandKRTAP2-2KRTAP2-3: 41,059,240–41,060,114, reverse strandKRTAP2-4: 41,065,116–41,065,879, reverse strandKRTAP4-7: 41,084,150–41,085,144, forward strandKRTAP4-7KRTAP4-8: 41,096,981–41,098,142, reverse strandKRTAP4-8KRTAP4-16: 41,101,502–41,102,209, reverse strandKRTAP4-9: 41,105,389–41,106,488, forward strandKRTAP4-11: 41,117,181–41,118,373, reverse strandKRTAP4-12: 41,123,091–41,124,182, reverse strandKRTAP4-6: 41,139,433–41,140,544, reverse strandKRTAP4-6KRTAP4-5: 41,148,924–41,149,825, reverse strandKRTAP4-4: 41,159,649–41,160,748, reverse strandKRTAP4-3: 41,167,231–41,168,221, reverse strandKRTAP4-3KRTAP4-2: 41,177,446–41,178,221, reverse strandKRTAP4-2KRTAP4-1: 41,184,100–41,184,911, reverse strandKRTAP9-1: 41,189,887–41,190,639, forward strandKRTAP9-2: 41,226,648–41,227,652, forward strandKRTAP9-2KRTAP9-3: 41,232,449–41,233,454, forward strandKRTAP9-8: 41,237,999–41,239,004, forward strandKRTAP9-4: 41,249,687–41,250,653, forward strandKRTAP9-4KRTAP9-9: 41,255,384–41,256,364, forward strandKRTAP9-9KRTAP9-6: 41,265,378–41,265,860, forward strandKRTAP9-7: 41,275,698–41,276,207, forward strandKRTAP29-1: 41,301,826–41,302,851, reverse strandKRTAP16-1: 41,307,700–41,309,309, reverse strandKRTAP17-1: 41,314,912–41,315,710, reverse strandKRTAP17-1KRT33A: 41,345,665–41,350,828, reverse strandKRT33AKRT33B: 41,363,498–41,369,813, reverse strandKRT33BDiagram of KRT12: 8 exons on the reverse strand of chromosome 17Exon 8: 40,861,303–40,861,758, 456 basesExon 7: 40,862,565–40,862,635, 71 basesExon 6: 40,863,123–40,863,343, 221 basesExon 5: 40,863,485–40,863,610, 126 basesExon 4: 40,863,703–40,863,864, 162 basesExon 3: 40,864,806–40,864,962, 157 basesExon 2: 40,866,155–40,866,237, 83 basesExon 1: 40,866,620–40,867,223, 604 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 5.9 kb; 1,485 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT12 gene: keratin 12. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt12

Vancouver

Dante Labs. KRT12 gene: keratin 12 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt12

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