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Gene

RSPO4

R-spondin 4

Summary

Cytogenetic location
20p13
Coordinates
Chromosome 20: 958,452–1,002,311 (GRCh38)
Exons
5 exons across 43.9 kb
Protein
234 amino acids
Also known as
dJ824F16.3
Previous symbols
C20orf182
MANE Select transcript
ENST00000217260.9NM_001029871.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads RSPO4 yet. The test sequences your whole genome, so your data includes it all the same.

How RSPO4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where RSPO4 sits. RSPO4 and 18 genes near it on chromosome 20, from 480,382 to 1,480,381.Chromosome 2020p13p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.330.6 Mb0.8 Mb1 Mb1.2 Mb1.4 MbCSNK2A1: 472,498–543,835, reverse strandCSNK2A1TCF15: 603,801–610,316, reverse strandTCF15SRXN1: 646,614–653,404, reverse strandSRXN1: 646,626–675,800, reverse strandSCRT2: 661,596–675,802, reverse strandSCRT2SLC52A3: 758,695–776,015, reverse strandSLC52A3FAM110A: 833,707–857,463, forward strandFAM110AANGPT4: 869,900–916,335, reverse strandANGPT4RSPO4: 958,452–1,002,311, reverse strandRSPO4PSMF1: 1,113,240–1,192,353, forward strandPSMF1TMEM74B: 1,178,989–1,186,842, reverse strandTMEM74BC20orf202: 1,203,454–1,209,076, forward strandC20orf202RAD21L1: 1,226,027–1,296,421, forward strandRAD21L1SNPH: 1,266,265–1,309,328, forward strandSNPHSDCBP2: 1,309,909–1,329,211, reverse strandSDCBP2: 1,317,571–1,393,096, reverse strandFKBP1A: 1,355,817–1,393,164, reverse strandFKBP1ANSFL1C: 1,442,162–1,473,842, reverse strandNSFL1CSIRPB2: 1,470,741–1,491,587, reverse strandSIRPB2Diagram of RSPO4: 5 exons on the reverse strand of chromosome 20Exon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 5: 958,452–960,466, 2,015 basesExon 4: 963,935–964,120, 186 basesExon 3: 967,174–967,314, 141 basesExon 2: 967,950–968,138, 189 basesExon 1: 1,002,086–1,002,311, 226 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 43.9 kb; 705 of those bases code for the protein.

How a genome test reads RSPO4

3

positions in RSPO4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 43.9 kb of RSPO4, introns included, not only the 2.8 kb of exons.

Traits linked to RSPO4

The Human Phenotype Ontology lists these as features of the rare conditions RSPO4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RSPO4 gene: R-spondin 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/rspo4

Vancouver

Dante Labs. RSPO4 gene: R-spondin 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rspo4

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