Traits

Traits linked to GLIS3

GLIS family zinc finger 3

The Human Phenotype Ontology links 36 traits to GLIS3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	Cât de frecvent apare
Hepatic fibrosis	Des (30–79%)
Pancreatic cysts	Uneori (5–29%)
Stomach hernia	Uneori (5–29%)
Umbilical hernia	Uneori (5–29%)
Underdeveloped pancreas	Uneori (5–29%)
Enlarged liver	Neînregistrat
Liver inflammation	Neînregistrat
Slowed or blocked flow of bile from liver	Neînregistrat

Abnormality of head or neck

Trait	Cât de frecvent apare
Blockage of the rear opening of the nasal cavity	Uneori (5–29%)
Early closure of midline skull joint	Uneori (5–29%)
Wider-than-typical soft spot of skull	Uneori (5–29%)
Depressed nasal bridge	Neînregistrat
Eye folds	Neînregistrat
Long philtrum	Neînregistrat
Thin red part of the upper lip	Neînregistrat

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Portal hypertension	Des (30–79%)
Cyst on spleen	Uneori (5–29%)
Increased spleen size	Uneori (5–29%)

Abnormality of the endocrine system

Trait	Cât de frecvent apare
Decreased circulating T4 concentration	Întotdeauna
Elevated circulating thyroid-stimulating hormone concentration	Întotdeauna
Underactive thyroid gland from birth	Întotdeauna

Abnormality of the eye

Trait	Cât de frecvent apare
Enlarged eyeball	Des (30–79%)
High eye pressure	Des (30–79%)
Developmental glaucoma	Neînregistrat

Abnormality of the ear

Trait	Cât de frecvent apare
Sensorineural hearing impairment	Uneori (5–29%)
Low-set ears	Neînregistrat

Abnormality of the genitourinary system

Trait	Cât de frecvent apare
Cystic kidney disease	Des (30–79%)
Polycystic kidney dysplasia	Neînregistrat

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Osteopenia	Uneori (5–29%)
Thoracolumbar scoliosis	Uneori (5–29%)

Abnormality of the nervous system

Trait	Cât de frecvent apare
Intellectual disability, mild	Des (30–79%)
Global developmental delay	Neînregistrat

Laboratory abnormality

Trait	Cât de frecvent apare
Diabetes mellitus	Întotdeauna
Elevated circulating thyroglobulin concentration	Întotdeauna

Abnormality of the immune system

Trait	Cât de frecvent apare
Recurrent infections	Uneori (5–29%)

Growth abnormality

Trait	Cât de frecvent apare
Prenatal growth deficiency	Întotdeauna

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GLIS3 and how often each is seen. Find out more at hpo.jax.org.

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