Traits

Traits linked to TRIP11

thyroid hormone receptor interactor 11

The Human Phenotype Ontology links 101 traits to TRIP11, by body system: features seen in people with one of the gene's rare conditions.

TRIP11

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bell-shaped thorax	Always
Disproportionate short-trunked short stature	Always
Flaring of rib cage	Always
Multiple rib fractures	Always
Narrow chest	Always
Short ribs	Always
Shorter than typical length between neck and abdomen	Always
Small sacrum	Always
Spondylometaphyseal dysplasia	Always
Abnormal enchondral ossification	Very often (80–99%)
Cone-shaped end part of bone	Very often (80–99%)
Double-Jointed	Very often (80–99%)
Flattened vertebrae	Very often (80–99%)
Lethal skeletal dysplasia	Very often (80–99%)
Abnormal ischium ossification	Often (30–79%)
Recurrent fractures	Often (30–79%)
Scoliosis	Often (30–79%)
Square pelvis bone	Often (30–79%)
Barrel-shaped chest	Not recorded
Biconvex vertebral bodies	Not recorded
Broad collarbone	Not recorded
Coronal cleft vertebrae	Not recorded
Crescent-shaped iliac bone	Not recorded
Flared iliac wing	Not recorded
Hypoplastic ischia	Not recorded
Irregular end part of long bone	Not recorded
Osteoporosis	Not recorded
Pigeon chest	Not recorded
Short collarbone	Not recorded
Short long bone	Not recorded
Small end part of bone	Not recorded
Small shoulder blade	Not recorded
Unossified vertebral bodies	Not recorded

Abnormality of limbs

Trait	How often it is seen
Bowed legs	Always
Bowing of the arm	Always
Club feet	Always
Severe limb shortening	Always
Short fingers or toes	Always
Smaller or shorter than typical limbs	Always
Abnormality of the wide portion of a long bone	Very often (80–99%)
Short palm	Very often (80–99%)
Coxa valga	Often (30–79%)
Short foot	Often (30–79%)
Bowing of the long bones	Sometimes (5–29%)
Abnormal foot bone ossification	Not recorded
Abnormal maturation of the hand bones	Not recorded
Abnormality of the wide portion of the femoral bone	Not recorded
Back knee	Not recorded
Broad wide portion of long bone	Not recorded
Cone-shaped end part of finger bones	Not recorded
Delayed maturation of wrist bone	Not recorded
Disproportionately short middle portion of limb	Not recorded
Flat acetabular roof	Not recorded
Metaphyseal cupping	Not recorded
Outward bow-leggedness	Not recorded
Short finger bones	Not recorded
Shortened long bone of hand	Not recorded
Underdeveloped outer large forearm bone	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Always
Decreased bone formation of skull	Always
Decreased size of nasal bridge	Always
Depressed nasal bridge	Always
Flat face	Always
Increased nuchal translucency	Always
Protruding tongue	Always
Short neck	Always
Short nose	Always
Tall shaped head	Always
Dentinogenesis imperfecta	Very often (80–99%)
Frontal bossing	Very often (80–99%)
Little lower jaw	Very often (80–99%)
Long philtrum	Very often (80–99%)
Nasal tip, upturned	Very often (80–99%)
Thickened skin folds of neck	Very often (80–99%)
Delayed eruption of teeth	Often (30–79%)
Cystic hygroma	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Narrow face	Not recorded
Prominent forehead	Not recorded
Relatively large head	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Belly sticks out	Always
Abdominal bloating	Very often (80–99%)
Femoral hernia	Often (30–79%)
Umbilical hernia	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Poorly developed lungs	Always
Absent/small lungs	Very often (80–99%)
Breathing difficulties	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Severe short stature	Very often (80–99%)
Short stature	Very often (80–99%)
Mesomelic short stature	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Absence of stomach bubble on fetal sonography	Always
High levels of amniotic fluid	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)
Patent ductus arteriosus	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Nephronophthisis	Sometimes (5–29%)
Polycystic kidney dysplasia	Not recorded

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Motor delay	Not recorded

Laboratory abnormality

Trait	How often it is seen
Hydrops fetalis	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRIP11 and how often each is seen. Find out more at hpo.jax.org.

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