Trait

Lip pits at corners of the mouth

Clinical name: Commissural lip pit

A depression located at an oral commissure.

HPO HP:0002710

Also called: Pits at the corners of the lips, Commissural labial pits, Commissural pit
Body system: Abnormality of head or neck Abnormality of the integument

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/commissural-lip-pit.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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2 genes linked to Lip pits at corners of the mouth

Changes in these genes cause rare conditions in which Lip pits at corners of the mouth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
RIPK4receptor interacting serine/threonine kinase 4	Often (30–79%)	In 2 conditions
SIX1SIX homeobox 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Lip pit

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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