Trait

Imperforate hymen

A congenital disorder where the hymen (a membrane that surrounds or partially covers the external vaginal opening) does not have an opening and completely obstructs the vagina.

HPO HP:0030011

Body system: Abnormality of the genitourinary system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/imperforate-hymen.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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5 genes linked to Imperforate hymen

Changes in these genes cause rare conditions in which Imperforate hymen is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ITPR1inositol 1,4,5-trisphosphate receptor type 1	Always	In 1 condition
RIPK4receptor interacting serine/threonine kinase 4	Often (30–79%)	In 1 condition
ZMYM2zinc finger MYM-type containing 2	Sometimes (5–29%)	In 1 condition
ARHGAP31Rho GTPase activating protein 31	Not recorded	In 1 condition
TBX3T-box transcription factor 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal vagina morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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