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Trait

Abnormal peripheral myelination

An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense.

HPO HP:0003130

Summary

Body system
Abnormality of the nervous system

4 genes linked to Abnormal peripheral myelination

Changes in these genes cause rare conditions in which Abnormal peripheral myelination is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DHHdesert hedgehog signaling moleculeVery often (80–99%)In 1 condition
MORC2MORC family CW-type zinc finger 2Often (30–79%)In 1 condition
ERCC6ERCC excision repair 6, chromatin remodeling factorNot recordedIn 1 condition
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunitNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal myelinationAbnormal peripheral nervous system structure

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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