Trait
Hand muscle weakness
Reduced strength of the musculature of the hand.
Summary
Reference genomeGRCh38hg38
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Get my Genome Test31 genes linked to Hand muscle weakness
Changes in these genes cause rare conditions in which Hand muscle weakness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARHGAP19Rho GTPase activating protein 19 | Always | In 1 condition |
| CAV3caveolin 3 | Always | In 1 condition |
| HSPB3heat shock protein family B (small) member 3 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| PDK3pyruvate dehydrogenase kinase 3 | Always | In 1 condition |
| PMP22peripheral myelin protein 22 | Always | In 2 conditions |
| SNUPNsnurportin 1 | Always | In 1 condition |
| YARS1tyrosyl-tRNA synthetase 1 | Always | In 1 condition |
| MATR3matrin 3 | Very often (80–99%) | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Often (30–79%) | In 2 conditions |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| MFN2mitofusin 2 | Often (30–79%) | In 1 condition |
| NEFLneurofilament light chain | Often (30–79%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Sometimes (5–29%) | In 1 condition |
| GJB1gap junction protein beta 1 | Sometimes (5–29%) | In 1 condition |
| GYG1glycogenin 1 | Sometimes (5–29%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| REEP1receptor accessory protein 1 | Sometimes (5–29%) | In 1 condition |
| RRM1ribonucleotide reductase catalytic subunit M1 | Sometimes (5–29%) | In 1 condition |
| SBF2SET binding factor 2 | Sometimes (5–29%) | In 1 condition |
| TK2thymidine kinase 2 | Sometimes (5–29%) | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Sometimes (5–29%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Rarely (1–4%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Rarely (1–4%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Rarely (1–4%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Rarely (1–4%) | In 1 condition |
| DCTN1dynactin subunit 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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