Trait
Claw hand deformity
An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test10 genes linked to Claw hand deformity
Changes in these genes cause rare conditions in which Claw hand deformity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Always | In 1 condition |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Often (30–79%) | In 1 condition |
| HSPB1heat shock protein family B (small) member 1 | Often (30–79%) | In 1 condition |
| NDRG1N-myc downstream regulated 1 | Often (30–79%) | In 1 condition |
| PDXKpyridoxal kinase | Often (30–79%) | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Often (30–79%) | In 1 condition |
| HK1hexokinase 1 | Not recorded | In 1 condition |
| INF2inverted formin 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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