Trait
Prolonged QT interval
Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).
Summary
- Also called
- Long QT syndrome, Prolong qt interval on ekg
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Prolonged QT interval, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test40 genes linked to Prolonged QT interval
Changes in these genes cause rare conditions in which Prolonged QT interval is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG10BALG10 alpha-1,2-glucosyltransferase B | Always | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 2 conditions |
| CAV3caveolin 3 | Always | In 1 condition |
| KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1 | Always | In 1 condition |
| KCNH2potassium voltage-gated channel subfamily H member 2 | Always | In 1 condition |
| TECRLtrans-2,3-enoyl-CoA reductase like | Always | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Very often (80–99%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Often (30–79%) | In 1 condition |
| DNAJC19DnaJ heat shock protein family (Hsp40) member C19 | Often (30–79%) | In 2 conditions |
| GPC3glypican 3 | Often (30–79%) | In 1 condition |
| GPC4glypican 4 | Often (30–79%) | In 1 condition |
| KCND3potassium voltage-gated channel subfamily D member 3 | Often (30–79%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Often (30–79%) | In 2 conditions |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Often (30–79%) | In 2 conditions |
| SLC12A3solute carrier family 12 member 3 | Often (30–79%) | In 2 conditions |
| SLC6A8solute carrier family 6 member 8 | Often (30–79%) | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Often (30–79%) | In 1 condition |
| ANK2ankyrin 2 | Sometimes (5–29%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Sometimes (5–29%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 3 conditions |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| STX16syntaxin 16 | Sometimes (5–29%) | In 1 condition |
| TNNT2troponin T2, cardiac type | Sometimes (5–29%) | In 1 condition |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Sometimes (5–29%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Rarely (1–4%) | In 1 condition |
| HADHhydroxyacyl-CoA dehydrogenase | Rarely (1–4%) | In 1 condition |
| CALM1calmodulin 1 | Not recorded | In 1 condition |
| CAVIN1caveolae associated protein 1 | Not recorded | In 1 condition |
| KCNE2potassium voltage-gated channel subfamily E regulatory subunit 2 | Not recorded | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Not recorded | In 2 conditions |
| SCN4Bsodium voltage-gated channel beta subunit 4 | Not recorded | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks