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Gene

CYCS

cytochrome c, somatic

Summary

Cytogenetic location
7p15.3
Coordinates
Chromosome 7: 25,118,656–25,125,260 (GRCh38)
Exons
3 exons across 6.6 kb
Protein
105 amino acids
Also known as
HCS, CYC
MANE Select transcript
ENST00000305786.7NM_018947.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How CYCS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where CYCS sits. CYCS and 5 genes near it on chromosome 7, from 24,621,958 to 25,621,957.Chromosome 77p15.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.324.8 Mb25 Mb25.2 Mb25.4 Mb25.6 MbPALS2: 24,572,936–24,694,193, forward strandPALS2GSDME: 24,698,301–24,757,992, reverse strandGSDMEOSBPL3: 24,796,536–24,981,634, reverse strandOSBPL3CYCS: 25,118,656–25,125,260, reverse strandCYCSSPMIP4: 25,134,676–25,180,385, reverse strandSPMIP4NPVF: 25,224,570–25,228,486, reverse strandNPVFDiagram of CYCS: 3 exons on the reverse strand of chromosome 7Exon 3: 2 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 3: 25,118,656–25,123,849, 5,194 basesExon 2: 25,123,951–25,124,127, 177 basesExon 1: 25,125,200–25,125,260, 61 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 6.6 kb; 318 of those bases code for the protein.

How a genome test reads CYCS

4

positions in CYCS where ClinVar classes a change as pathogenic or likely pathogenic

4 of them (100%) fall in regions short reads find hard.

  • Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (4 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 6.6 kb of CYCS, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CYCS gene: cytochrome c, somatic. Retrieved 16 October 2026, from https://dantelabs.com/genes/cycs

Vancouver

Dante Labs. CYCS gene: cytochrome c, somatic [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cycs

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