Trait

Bleeding within a joint

Clinical name: Joint hemorrhage

Hemorrhage occurring within a joint.

HPO HP:0005261

Also called: Hemarthrosis, Hemarthroses, Spontaneous joint haemorrhage, Spontaneous joint hemorrhage
Body system: Abnormality of blood and blood-forming tissues Abnormality of the cardiovascular system Abnormality of the musculoskeletal system

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18 genes linked to Bleeding within a joint

Changes in these genes cause rare conditions in which Bleeding within a joint is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
F7coagulation factor VII	Always	In 2 conditions
F9coagulation factor IX	Very often (80–99%)	In 1 condition
SERPINF2serpin family F member 2	Very often (80–99%)	In 2 conditions
F13A1coagulation factor XIII A chain	Often (30–79%)	In 2 conditions
F13Bcoagulation factor XIII B chain	Often (30–79%)	In 1 condition
F2coagulation factor II, thrombin	Often (30–79%)	In 2 conditions
F5coagulation factor V	Often (30–79%)	In 1 condition
F8coagulation factor VIII	Often (30–79%)	In 4 conditions
F10coagulation factor X	Sometimes (5–29%)	In 2 conditions
GGCXgamma-glutamyl carboxylase	Sometimes (5–29%)	In 2 conditions
LMAN1lectin, mannose binding 1	Sometimes (5–29%)	In 1 condition
MCFD2multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Sometimes (5–29%)	In 1 condition
VKORC1vitamin K epoxide reductase complex subunit 1	Sometimes (5–29%)	In 1 condition
VWFvon Willebrand factor	Sometimes (5–29%)	In 2 conditions
F11coagulation factor XI	Rarely (1–4%)	In 1 condition
SERPINE1serpin family E member 1	Rarely (1–4%)	In 1 condition
PLAUplasminogen activator, urokinase	Not recorded	In 1 condition
WASWASP actin nucleation promoting factor	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal shape of joints Internal bleeding

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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