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Gene

HRG

histidine rich glycoprotein

Summary

Cytogenetic location
3q27.3
Coordinates
Chromosome 3: 186,666,014–186,678,234 (GRCh38)
Exons
7 exons across 12.2 kb
Protein
525 amino acids
Also known as
HRGP, HPRG
MANE Select transcript
ENST00000232003.5NM_000412.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Thrombophilia

    • Inherited Thrombophilia
      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Anticoagulation (duration by genotype); avoid estrogen-containing contraceptives; LMWH for pregnancy prophylaxis; extended post-surgical anticoagulation; lifelong anticoagulation for compound/high-risk genotypes

How HRG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where HRG sits. HRG and 13 genes near it on chromosome 3, from 186,172,124 to 187,172,123.Chromosome 33q27.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29186.2 Mb186.4 Mb186.6 Mb186.8 Mb187 MbDGKG: 186,105,668–186,362,326, reverse strandDGKGCRYGS: 186,536,578–186,546,702, reverse strandCRYGSTBCCD1: 186,546,024–186,570,543, reverse strandTBCCD1DNAJB11: 186,567,403–186,585,800, forward strandDNAJB11: 186,581,995–186,597,103, forward strandAHSG: 186,612,776–186,627,803, forward strandAHSGFETUB: 186,634,558–186,654,352, forward strandFETUBHRG: 186,666,014–186,678,234, forward strandHRGKNG1: 186,717,329–186,744,736, forward strandKNG1EIF4A2: 186,783,205–186,789,901, forward strandEIF4A2RFC4: 186,789,866–186,807,058, reverse strandRFC4ADIPOQ: 186,842,674–186,858,463, forward strandADIPOQST6GAL1: 186,930,325–187,078,932, forward strandST6GAL1RPL39L: 187,120,927–187,180,972, reverse strandRPL39LDiagram of HRG: 7 exons on the forward strand of chromosome 3Exon 1: 186,666,014–186,666,214, 201 basesExon 2: 186,668,935–186,669,051, 117 basesExon 3: 186,669,938–186,670,028, 91 basesExon 4: 186,671,623–186,671,789, 167 basesExon 5: 186,672,787–186,672,867, 81 basesExon 6: 186,675,089–186,675,190, 102 basesExon 7: 186,677,047–186,678,234, 1,188 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 12.2 kb; 1,578 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HRG gene: histidine rich glycoprotein. Retrieved 17 October 2026, from https://dantelabs.com/genes/hrg

Vancouver

Dante Labs. HRG gene: histidine rich glycoprotein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hrg

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