Traits

Traits linked to CRKL

CRK like proto-oncogene, adaptor protein

The Human Phenotype Ontology links 60 traits to CRKL, by body system: features seen in people with one of the gene's rare conditions.

CRKL

Abnormality of head or neck

Trait	How often it is seen
Highly arched eyebrow	Very often (80–99%)
Smooth philtrum	Very often (80–99%)
Abnormally small head	Often (30–79%)
Pointed chin	Often (30–79%)
Thin red part of the upper lip	Often (30–79%)
Underdeveloped tissue around nostril	Often (30–79%)
Blockage of the rear opening of the nasal cavity	Sometimes (5–29%)
Branchial fistula	Sometimes (5–29%)
Cleft palate	Sometimes (5–29%)
Facial asymmetry	Sometimes (5–29%)
High, narrow palate	Sometimes (5–29%)
Long face	Sometimes (5–29%)
Narrow mouth	Sometimes (5–29%)
Narrow opening between the eyelids	Sometimes (5–29%)
Prominent nasal bridge	Sometimes (5–29%)
Tongue tied	Sometimes (5–29%)
Zygomatic flattening	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Often (30–79%)
Dropped arches	Often (30–79%)
Bowing of the long bones	Sometimes (5–29%)
Coxa valga	Sometimes (5–29%)
Finger bends toward pinky	Sometimes (5–29%)
Fused toes	Sometimes (5–29%)
Gap between 1st and 2nd toes	Sometimes (5–29%)
Long slender fingers	Sometimes (5–29%)
Permanent flexion of the finger	Sometimes (5–29%)
Short outermost finger bone	Sometimes (5–29%)
Short palm	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Language impairment	Very often (80–99%)
Attention deficit	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Obsessive compulsive behavior	Sometimes (5–29%)
Tic disorder	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Truncus arteriosus	Often (30–79%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Aortic regurgitation	Sometimes (5–29%)
Bulge in wall of large artery that carries blood away from heart	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Inguinal hernia	Sometimes (5–29%)
Loss of bowel control	Sometimes (5–29%)
Pyloric stenosis	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Very often (80–99%)
Prenatal growth deficiency	Often (30–79%)
Growth delay	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Abnormal earlobe	Often (30–79%)
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Deeply set eye	Often (30–79%)
Oculomotor apraxia	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Sometimes (5–29%)
Recurrent respiratory infections	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Absent fingernail	Often (30–79%)
Absent toenail	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Sometimes (5–29%)
Prominent swayback	Sometimes (5–29%)

Abnormal tissue mass

Trait	How often it is seen
Abnormal tissue mass	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature birth	Very often (80–99%)

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CRKL and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test