Trait
Prolonged QTc interval
A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test29 genes linked to Prolonged QTc interval
Changes in these genes cause rare conditions in which Prolonged QTc interval is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AKAP9A-kinase anchoring protein 9 | Always | In 1 condition |
| ALG10BALG10 alpha-1,2-glucosyltransferase B | Always | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 1 condition |
| CALM1calmodulin 1 | Always | In 1 condition |
| CALM2calmodulin 2 | Always | In 1 condition |
| CALM3calmodulin 3 | Always | In 1 condition |
| GYS1glycogen synthase 1 | Always | In 1 condition |
| KCNE2potassium voltage-gated channel subfamily E regulatory subunit 2 | Always | In 1 condition |
| KCNH2potassium voltage-gated channel subfamily H member 2 | Always | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Always | In 4 conditions |
| NRAPnebulin related anchoring protein | Always | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Always | In 1 condition |
| SNTA1syntrophin alpha 1 | Always | In 1 condition |
| KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1 | Very often (80–99%) | In 2 conditions |
| ALPK3alpha kinase 3 | Often (30–79%) | In 1 condition |
| KCNA5potassium voltage-gated channel subfamily A member 5 | Often (30–79%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Often (30–79%) | In 2 conditions |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Often (30–79%) | In 2 conditions |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Often (30–79%) | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Often (30–79%) | In 1 condition |
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Sometimes (5–29%) | In 1 condition |
| ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| FLNCfilamin C | Sometimes (5–29%) | In 1 condition |
| HCN4hyperpolarization activated cyclic nucleotide gated potassium channel 4 | Sometimes (5–29%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Sometimes (5–29%) | In 1 condition |
| SVILsupervillin | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
| TNNI3KTNNI3 interacting kinase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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