Traits

Traits linked to TRIO

trio Rho guanine nucleotide exchange factor

The Human Phenotype Ontology links 106 traits to TRIO, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	Kui sageli seda täheldatakse
Abnormal dentition	Sageli (30–79%)
Abnormally small head	Sageli (30–79%)
Big calvaria	Sageli (30–79%)
Dental crowding	Sageli (30–79%)
Facial asymmetry	Sageli (30–79%)
Frontal bossing	Sageli (30–79%)
Full lips	Sageli (30–79%)
Fullness around the eyes	Sageli (30–79%)
High forehead	Sageli (30–79%)
Little lower jaw	Sageli (30–79%)
Monobrow	Sageli (30–79%)
Small head present at birth	Sageli (30–79%)
Bulbous nose	Mõnikord (5–29%)
Depressed nasal bridge	Mõnikord (5–29%)
Development of small head that was not present at birth	Mõnikord (5–29%)
Downward slanting of the opening between the eyelids	Mõnikord (5–29%)
Eye folds	Mõnikord (5–29%)
Failure of development of more than six teeth	Mõnikord (5–29%)
Failure of eruption of tooth	Mõnikord (5–29%)
High palate	Mõnikord (5–29%)
Highly arched eyebrow	Mõnikord (5–29%)
Long philtrum	Mõnikord (5–29%)
Low frontal hairline	Mõnikord (5–29%)
Low hanging columella	Mõnikord (5–29%)
Midface retrusion	Mõnikord (5–29%)
Nasal tip, upturned	Mõnikord (5–29%)
Prominent nasal bridge	Mõnikord (5–29%)
Receding chin	Mõnikord (5–29%)
Short chin	Mõnikord (5–29%)
Short nose	Mõnikord (5–29%)
Short philtrum	Mõnikord (5–29%)
Slanting of the opening between the eyelids	Mõnikord (5–29%)
Thick eyebrow	Mõnikord (5–29%)
Thin red part of the upper lip	Mõnikord (5–29%)
Underdeveloped tissue around nostril	Mõnikord (5–29%)
Upward slanting of the opening between the eyelids	Mõnikord (5–29%)
Wide mouth	Mõnikord (5–29%)
Wide nasal bridge	Mõnikord (5–29%)

Abnormality of the nervous system

Trait	Kui sageli seda täheldatakse
Delayed ability to walk	Alati
Delayed speech and language development	Alati
Intellectual disability	Alati
Motor delay	Alati
Global developmental delay	Väga sageli (80–99%)
Intellectual disability, mild	Väga sageli (80–99%)
Poor speech	Väga sageli (80–99%)
Aggressive behavior	Sageli (30–79%)
Attention deficit	Sageli (30–79%)
Autism spectrum disorder	Sageli (30–79%)
Behavioral abnormality	Sageli (30–79%)
Epilepsy	Sageli (30–79%)
Increased reflexes	Sageli (30–79%)
Obsessive-compulsive trait	Sageli (30–79%)
Repetitive movements	Sageli (30–79%)
Absent speech development	Mõnikord (5–29%)
Delayed ability to sit	Mõnikord (5–29%)
Difficulty sleeping	Mõnikord (5–29%)
Hyperacusis	Mõnikord (5–29%)
Inability to coordinate movements when walking	Mõnikord (5–29%)
Intellectual disability, borderline	Mõnikord (5–29%)
Obsessive compulsive behavior	Mõnikord (5–29%)
Pain insensitivity	Mõnikord (5–29%)
Self-injurious behavior	Mõnikord (5–29%)
Self-mutilation	Mõnikord (5–29%)
Specific learning disability	Mõnikord (5–29%)
Tremor	Mõnikord (5–29%)

Abnormality of limbs

Trait	Kui sageli seda täheldatakse
Tapered finger	Sageli (30–79%)
Webbed 2nd and 3rd toes	Sageli (30–79%)
Abnormality of the hand	Mõnikord (5–29%)
Absent 1st long bone of hand	Mõnikord (5–29%)
Curvature of little finger	Mõnikord (5–29%)
Dropped arches	Mõnikord (5–29%)
Gap between 1st and 2nd toes	Mõnikord (5–29%)
Partial absence of thumb	Mõnikord (5–29%)
Short fingers or toes	Mõnikord (5–29%)
Short palm	Mõnikord (5–29%)
Single transverse palmar crease	Mõnikord (5–29%)
Unilateral radial aplasia	Mõnikord (5–29%)
Winged shoulder blade	Mõnikord (5–29%)

Abnormality of the digestive system

Trait	Kui sageli seda täheldatakse
Chronic constipation	Sageli (30–79%)
Feeding difficulties	Sageli (30–79%)
Feeding difficulties in infancy	Sageli (30–79%)
Poor swallowing	Sageli (30–79%)
Gastrostomy tube feeding in infancy	Mõnikord (5–29%)
Poor suck	Mõnikord (5–29%)

Abnormality of the eye

Trait	Kui sageli seda täheldatakse
Congenital drooping upper eyelid	Mõnikord (5–29%)
Cross-eyed	Mõnikord (5–29%)
Drooping upper eyelid	Mõnikord (5–29%)
Lazy eye	Mõnikord (5–29%)
Wide-set eyes	Mõnikord (5–29%)

Abnormality of the cardiovascular system

Trait	Kui sageli seda täheldatakse
An opening in the wall separating the top two chambers of the heart	Mõnikord (5–29%)
Complete atrioventricular canal defect	Mõnikord (5–29%)
Hole in heart wall separating two lower heart chambers	Mõnikord (5–29%)
Patent ductus arteriosus	Mõnikord (5–29%)

Abnormality of the musculoskeletal system

Trait	Kui sageli seda täheldatakse
Hunched back	Sageli (30–79%)
Scoliosis	Sageli (30–79%)
Funnel chest	Mõnikord (5–29%)
Low muscle tone	Mõnikord (5–29%)

Abnormality of the ear

Trait	Kui sageli seda täheldatakse
Large ears	Mõnikord (5–29%)
Overfolded ears	Mõnikord (5–29%)

Abnormality of the integument

Trait	Kui sageli seda täheldatakse
Excessive hairiness	Mõnikord (5–29%)
Frontal upsweep of hair	Mõnikord (5–29%)

Abnormality of the genitourinary system

Trait	Kui sageli seda täheldatakse
Loss of bladder control	Mõnikord (5–29%)

Abnormality of the immune system

Trait	Kui sageli seda täheldatakse
Recurrent infections	Alati

Constitutional symptom

Trait	Kui sageli seda täheldatakse
Fatigue	Sageli (30–79%)

Growth abnormality

Trait	Kui sageli seda täheldatakse
Faltering weight	Mõnikord (5–29%)

Laboratory abnormality

Trait	Kui sageli seda täheldatakse
High blood calcium levels	Mõnikord (5–29%)

Kui sageli see esineb geenist tulenevate seisunditega inimeste seas, kõige sagedamini nende kõigi seas, nagu on märgitud Inimese fenotüübi ontoloogias. Need lehed kirjeldavad tunnuseid ja nende taga olevaid uuringuid; need ei ole diagnoos ning sümptomite kohta tuleks küsida arstilt või geneetilt nõustajalt.

Allikas

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRIO and how often each is seen. Find out more at hpo.jax.org.

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