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Gene

KIDINS220

kinase D interacting substrate 220

Summary

Cytogenetic location
2p25.1
Coordinates
Chromosome 2: 8,728,858–8,837,613 (GRCh38)
Exons
30 exons across 108.8 kb
Protein
1,771 amino acids
Also known as
ARMS
MANE Select transcript
ENST00000256707.8NM_020738.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How KIDINS220 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 2, with a bracket where KIDINS220 sits. KIDINS220 and 3 genes near it on chromosome 2, from 8,283,236 to 9,283,235.Chromosome 22p25.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.38.4 Mb8.6 Mb8.8 Mb9 Mb9.2 MbID2: 8,678,845–8,684,461, forward strandID2KIDINS220: 8,728,858–8,837,613, reverse strandKIDINS220MBOAT2: 8,852,473–9,003,859, reverse strandMBOAT2ASAP2: 9,206,602–9,405,683, forward strandASAP2Diagram of KIDINS220: 30 exons on the reverse strand of chromosome 2Exon 30: 9 known disease-causing sitesExon 29: 3 known disease-causing sitesExon 25: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 30: 8,728,858–8,731,982, 3,125 basesExon 29: 8,733,444–8,733,680, 237 basesExon 28: 8,734,655–8,734,753, 99 basesExon 27: 8,736,868–8,736,999, 132 basesExon 26: 8,747,145–8,747,201, 57 basesExon 25: 8,747,887–8,748,000, 114 basesExon 24: 8,750,112–8,750,335, 224 basesExon 23: 8,751,466–8,751,644, 179 basesExon 22: 8,770,670–8,770,832, 163 basesExon 21: 8,776,748–8,776,892, 145 basesExon 20: 8,778,639–8,778,727, 89 basesExon 19: 8,778,896–8,779,139, 244 basesExon 18: 8,779,674–8,779,814, 141 basesExon 17: 8,785,741–8,786,030, 290 basesExon 16: 8,786,206–8,786,357, 152 basesExon 15: 8,788,647–8,788,812, 166 basesExon 14: 8,789,880–8,790,059, 180 basesExon 13: 8,791,060–8,791,224, 165 basesExon 12: 8,793,810–8,793,987, 178 basesExon 11: 8,796,771–8,796,869, 99 basesExon 10: 8,798,202–8,798,300, 99 basesExon 9: 8,800,400–8,800,498, 99 basesExon 8: 8,802,930–8,803,127, 198 basesExon 7: 8,806,271–8,806,369, 99 basesExon 6: 8,812,395–8,812,493, 99 basesExon 5: 8,813,237–8,813,335, 99 basesExon 4: 8,817,618–8,817,716, 99 basesExon 3: 8,818,695–8,818,793, 99 basesExon 2: 8,826,986–8,827,129, 144 basesExon 1: 8,837,480–8,837,613, 134 bases3025201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.3 kb of the gene's 108.8 kb; 5,316 of those bases code for the protein.

    How a genome test reads KIDINS220

    20

    positions in KIDINS220 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 108.8 kb of KIDINS220, introns included, not only the 7.3 kb of exons.

    Genes linked to the same conditions

    Traits linked to KIDINS220

    The Human Phenotype Ontology lists these as features of the rare conditions KIDINS220 can cause. Each trait's page lists the other genes linked to it.

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KIDINS220 gene: kinase D interacting substrate 220. Retrieved 17 October 2026, from https://dantelabs.com/genes/kidins220

    Vancouver

    Dante Labs. KIDINS220 gene: kinase D interacting substrate 220 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kidins220

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