Traits

Traits linked to XIAP

X-linked inhibitor of apoptosis

The Human Phenotype Ontology links 50 traits to XIAP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low blood cell count	Always
Hypofibrinogenemia	Very often (80–99%)
Hemophagocytosis	Often (30–79%)
Splenic hemophagocytosis	Often (30–79%)
Burkitt lymphoma	Sometimes (5–29%)
Cancer of lymphatic system	Sometimes (5–29%)
Low blood neutrophil count	Sometimes (5–29%)
Reduced total natural killer cell count	Sometimes (5–29%)
Aplastic anemia	Rarely (1–4%)
High lymphocyte count	Not recorded
Low platelet count	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Very often (80–99%)
Recurrent respiratory infections	Often (30–79%)
Erythema nodosum	Sometimes (5–29%)
Meningitis	Sometimes (5–29%)
Recurrent infections	Sometimes (5–29%)
Severe Epstein Barr virus infection	Sometimes (5–29%)
Skin abscess	Sometimes (5–29%)
Acne	Not recorded
Brain inflammation	Not recorded
Folliculitis	Not recorded
Recurrent skin infections	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Liver inflammation	Very often (80–99%)
Crohn's disease	Often (30–79%)
Enlarged liver	Often (30–79%)
Jejunoileal ulceration	Often (30–79%)
Bile duct inflammation	Sometimes (5–29%)
Colitis	Sometimes (5–29%)
Fulminant hepatitis	Sometimes (5–29%)
Inflammation of the large intestine	Sometimes (5–29%)
Liver failure	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always
Episodic fever	Always
Low albumin	Always
Elevated serum ferritin	Very often (80–99%)
Fever	Very often (80–99%)
Increased plasma triglycerides	Very often (80–99%)

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal natural killer cell physiology	Always
Decreased circulating antibody level	Often (30–79%)
Decreased circulating IgG concentration	Often (30–79%)
Increased circulating IgM concentration	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Very often (80–99%)
Inflammation of blood vessel	Rarely (1–4%)
Swollen lymph nodes	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Kidney inflammation	Sometimes (5–29%)
Renal failure	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Recurrent sore throat	Not recorded

Abnormality of the eye

Trait	How often it is seen
Uveitis	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Hepatic encephalopathy	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to XIAP and how often each is seen. Find out more at hpo.jax.org.

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