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Gene

OPN1SW

opsin 1, short wave sensitive

Summary

Cytogenetic location
7q32.1
Coordinates
Chromosome 7: 128,772,485–128,775,794 (GRCh38)
Exons
5 exons across 3.3 kb
Protein
345 amino acids
Inheritance
Autosomal dominant
Also known as
BOP, CBT
Previous symbols
BCP
MANE Select transcript
ENST00000249389.3NM_001385125.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Colour Vision Deficiency

    • Blue Colour Vision Deficiency (Tritan)Autosomal dominant

      A rare dominant difference in colour vision caused by changes in OPN1SW, the gene for the blue-sensitive cone pigment.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How OPN1SW is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 7, with a bracket where OPN1SW sits. OPN1SW and 18 genes near it on chromosome 7, from 128,274,140 to 129,274,139.Chromosome 77q32.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3128.4 Mb128.6 Mb128.8 Mb129 Mb129.2 MbRBM28: 128,278,493–128,343,971, reverse strandRBM28PRRT4: 128,350,325–128,361,940, reverse strandPRRT4IMPDH1: 128,392,277–128,410,009, reverse strandIMPDH1HILPDA: 128,455,825–128,458,423, forward strandHILPDAMETTL2B: 128,476,729–128,506,602, forward strandMETTL2BGARIN1A: 128,671,693–128,687,877, forward strandGARIN1AGARIN1B: 128,709,061–128,731,743, forward strandGARIN1BCALU: 128,739,292–128,773,400, forward strandCALUOPN1SW: 128,772,485–128,775,794, reverse strandOPN1SWCCDC136: 128,790,750–128,822,135, forward strandCCDC136FLNC: 128,830,292–128,859,275, forward strandFLNCKCP: 128,862,042–128,910,719, reverse strandKCPATP6V1F: 128,862,816–128,865,849, forward strandATP6V1FSPMIP1: 128,866,330–128,872,047, forward strandSPMIP1IRF5: 128,933,429–128,950,389, forward strandIRF5TNPO3: 128,954,180–129,055,208, reverse strandTNPO3TSPAN33: 129,144,690–129,177,456, forward strandTSPAN33SMO: 129,188,501–129,213,546, forward strandSMOAHCYL2: 129,225,020–129,431,841, forward strandAHCYL2Diagram of OPN1SW: 5 exons on the reverse strand of chromosome 7Exon 5: 128,772,485–128,772,659, 175 basesExon 4: 128,773,649–128,773,888, 240 basesExon 3: 128,774,498–128,774,663, 166 basesExon 2: 128,774,986–128,775,154, 169 basesExon 1: 128,775,439–128,775,794, 356 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 3.3 kb; 1,038 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). OPN1SW gene: opsin 1, short wave sensitive. Retrieved 16 October 2026, from https://dantelabs.com/genes/opn1sw

Vancouver

Dante Labs. OPN1SW gene: opsin 1, short wave sensitive [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/opn1sw

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