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Trait

Abnormal circulating cytokine concentration

Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells.

HPO HP:0011112

Summary

Also called
Abnormality of serum cytokine level
Body system
Abnormality of the immune system

4 genes linked to Abnormal circulating cytokine concentration

Changes in these genes cause rare conditions in which Abnormal circulating cytokine concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
PRF1perforin 1Very often (80–99%)In 1 condition
STX11syntaxin 11Very often (80–99%)In 1 condition
STXBP2syntaxin binding protein 2Very often (80–99%)In 1 condition
UNC13Dunc-13 homolog DVery often (80–99%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal immune serum protein physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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