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Trait
Progressive spastic paraplegia
Progressive spastic paraplegiaHP:0007020
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Read the genes linked to Progressive spastic paraplegia, and the rest of your genome, with one test.
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Get my Genome Test33 genes linked to Progressive spastic paraplegia
Changes in these genes cause rare conditions in which Progressive spastic paraplegia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 1 condition |
| SELENOIselenoprotein I | Always | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Very often (80–99%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Very often (80–99%) | In 1 condition |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Very often (80–99%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Very often (80–99%) | In 1 condition |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Very often (80–99%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Very often (80–99%) | In 1 condition |
| CPT1Ccarnitine palmitoyltransferase 1C | Very often (80–99%) | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Very often (80–99%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Very often (80–99%) | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Very often (80–99%) | In 1 condition |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Very often (80–99%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Very often (80–99%) | In 1 condition |
| RTN2reticulon 2 | Very often (80–99%) | In 1 condition |
| SLC33A1solute carrier family 33 member 1 | Very often (80–99%) | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Very often (80–99%) | In 1 condition |
| WASHC5WASH complex subunit 5 | Very often (80–99%) | In 1 condition |
| ARSIarylsulfatase family member I | Often (30–79%) | In 1 condition |
| CCT5chaperonin containing TCP1 subunit 5 | Often (30–79%) | In 1 condition |
| FLRT1fibronectin leucine rich transmembrane protein 1 | Often (30–79%) | In 1 condition |
| KIDINS220kinase D interacting substrate 220 | Often (30–79%) | In 1 condition |
| KLC2kinesin light chain 2 | Often (30–79%) | In 1 condition |
| KYkyphoscoliosis peptidase | Often (30–79%) | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Often (30–79%) | In 1 condition |
| PLP1proteolipid protein 1 | Often (30–79%) | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Often (30–79%) | In 1 condition |
| ZFRzinc finger RNA binding protein | Often (30–79%) | In 1 condition |
| KDM5Clysine demethylase 5C | Not recorded | In 1 condition |
| PNPLA6patatin like domain 6, lysophospholipase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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