Traits

Traits linked to HMOX1

heme oxygenase 1

The Human Phenotype Ontology links 74 traits to HMOX1, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Always
Elevated circulating alanine aminotransferase concentration	Always
Elevated circulating aspartate aminotransferase concentration	Always
Elevated circulating C-reactive protein concentration	Always
Elevated serum ferritin	Always
High urine protein levels	Always
Increased circulating lactate dehydrogenase concentration	Always
Elevated sweat chloride	Very often (80–99%)
Episodic fever	Very often (80–99%)
Hypobilirubinemia	Very often (80–99%)
Elevated circulating haptoglobin concentration	Often (30–79%)
Elevated lipids in blood	Often (30–79%)
High liver enzymes	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bloody nose	Always
Coombs-positive hemolytic anemia	Always
Diffuse alveolar hemorrhage	Always
Hemolytic anemia	Always
Increased number of platelets in blood	Always
Elevated circulating D-dimer concentration	Often (30–79%)
Elevated white blood count	Often (30–79%)
Hypofibrinogenemia	Often (30–79%)
Low number of red blood cells or hemoglobin	Often (30–79%)
Bleeding within the skull	Sometimes (5–29%)
Howell-Jolly bodies	Sometimes (5–29%)
Schistocytosis	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Increased circulating interleukin 6 concentration	Always
Infection in blood stream	Always
Recurrent respiratory infections	Very often (80–99%)
Asthma	Sometimes (5–29%)
Recurrent Aspergillus infection	Sometimes (5–29%)
Recurrent chest infections	Sometimes (5–29%)
Recurrent Haemophilus influenzae infection	Sometimes (5–29%)
Recurrent Staphylococcus aureus infection	Sometimes (5–29%)
Nontuberculous mycobacterial pulmonary infection	Rarely (1–4%)
Recurrent Burkholderia cepacia infection	Rarely (1–4%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Inability to properly digest food due to lack of pancreatic digestive enzymes	Very often (80–99%)
Malabsorption	Very often (80–99%)
Abnormality of the liver	Sometimes (5–29%)
Acid reflux	Sometimes (5–29%)
Fat in feces	Sometimes (5–29%)
Meconium ileus	Sometimes (5–29%)
Rectum protrudes through anus	Sometimes (5–29%)
Scar tissue replaces healthy tissue in the liver	Rarely (1–4%)

Abnormality of the respiratory system

Trait	How often it is seen
Obstructive lung disease	Very often (80–99%)
Permanent enlargement of the airways of the lungs	Very often (80–99%)
Abnormality in area between air sacs in lung	Sometimes (5–29%)
Reduced forced expiratory volume in one second	Sometimes (5–29%)
Respiratory failure	Sometimes (5–29%)
Collapsed lung	Rarely (1–4%)
Coughing up blood	Rarely (1–4%)
Chronic pulmonary obstruction	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Chemosis	Always
Depressed nasal bridge	Sometimes (5–29%)
Frontal bossing	Sometimes (5–29%)
Sinus disease	Sometimes (5–29%)
Nasal polyposis	Rarely (1–4%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Absent spleen	Always
High blood pressure	Always
Swollen lymph nodes	Always
Swollen lymph nodes in the neck	Always
Underdeveloped spleen	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Kidney inflammation	Always
Absent vas deferens	Very often (80–99%)
Male infertility	Often (30–79%)
Kidney stone	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Growth delay	Always
Faltering weight	Often (30–79%)
Decreased body mass index	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Osteopenia	Sometimes (5–29%)
Osteoporosis	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Anxiety	Sometimes (5–29%)
Depression	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HMOX1 and how often each is seen. Find out more at hpo.jax.org.

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