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Trait

Elevated sweat chloride

An increased concentration of chloride in the sweat.

HPO HP:0012236

Summary

Also called
Elevated sweat Cl, Elevated sweat Cl-
Body system
Laboratory abnormality

12 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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24 genes linked to Elevated sweat chloride

Changes in these genes cause rare conditions in which Elevated sweat chloride is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CA12carbonic anhydrase 12AlwaysIn 1 condition
CFTRCF transmembrane conductance regulatorAlwaysIn 3 conditions
FCGR2AFc gamma receptor IIaAlwaysIn 1 condition
SCNN1Asodium channel epithelial 1 subunit alphaAlwaysIn 1 condition
TGFB1transforming growth factor beta 1AlwaysIn 2 conditions
CEACAM3CEA cell adhesion molecule 3Very often (80–99%)In 1 condition
CEACAM6CEA cell adhesion molecule 6Very often (80–99%)In 1 condition
CLCA4chloride channel accessory 4Very often (80–99%)In 1 condition
DCTN4dynactin subunit 4Very often (80–99%)In 1 condition
EDNRAendothelin receptor type AVery often (80–99%)In 1 condition
GCLCglutamate-cysteine ligase catalytic subunitVery often (80–99%)In 1 condition
GSTM3glutathione S-transferase mu 3Very often (80–99%)In 1 condition
HFEhomeostatic iron regulatorVery often (80–99%)In 1 condition
HMOX1heme oxygenase 1Very often (80–99%)In 1 condition
KCNN4potassium calcium-activated channel subfamily N member 4Very often (80–99%)In 1 condition
MIFmacrophage migration inhibitory factorVery often (80–99%)In 1 condition
SERPINA1serpin family A member 1Very often (80–99%)In 1 condition
SLC11A1solute carrier family 11 member 1Very often (80–99%)In 1 condition
SLC26A9solute carrier family 26 member 9Very often (80–99%)In 1 condition
SLC6A14solute carrier family 6 member 14Very often (80–99%)In 1 condition
SLC9A3solute carrier family 9 member A3Very often (80–99%)In 1 condition
STX1Asyntaxin 1AVery often (80–99%)In 1 condition
SCNN1Bsodium channel epithelial 1 subunit betaSometimes (5–29%)In 1 condition
FUCA1alpha-L-fucosidase 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal sweat homeostasis

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.21-777c9289.

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