Traits

Traits linked to FZD4

frizzled class receptor 4

The Human Phenotype Ontology links 63 traits to FZD4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Remnants of the hyaloid vascular system	Always
Vitreoretinopathy	Always
Abnormally small eyeball	Very often (80–99%)
Clouding of the lens of the eye	Very often (80–99%)
Corneal opacity	Very often (80–99%)
Decreased clarity of vision	Very often (80–99%)
Leukocoria	Very often (80–99%)
Retinopathy of prematurity	Very often (80–99%)
Abnormal optic disc morphology	Often (30–79%)
Angle closure glaucoma	Often (30–79%)
Clouding of the lens of the eye at birth	Often (30–79%)
Ectopic fovea	Often (30–79%)
Exudative vitreoretinopathy	Often (30–79%)
Eye floaters	Often (30–79%)
Falciform retinal fold	Often (30–79%)
Glial remnants anterior to the optic disc	Often (30–79%)
Hyaloid vascular remnant and retrolental mass	Often (30–79%)
Inward turning cross eyed	Often (30–79%)
Persistent pupillary membrane	Often (30–79%)
Retinal detachment	Often (30–79%)
Subretinal fluid	Often (30–79%)
Tractional retinal detachment	Often (30–79%)
Abnormal macular morphology	Sometimes (5–29%)
Blindness	Sometimes (5–29%)
Chorioretinal atrophy	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Cornea of eye less than 10mm in diameter	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Enlarged eyeball	Sometimes (5–29%)
Epiretinal membrane	Sometimes (5–29%)
Glaucoma	Sometimes (5–29%)
Increased tears	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)
Macular edema	Sometimes (5–29%)
Macular hypoplasia	Sometimes (5–29%)
Marked vision impairment	Sometimes (5–29%)
Phthisis bulbi	Sometimes (5–29%)
Retinal exudate	Sometimes (5–29%)
Retinal fold	Sometimes (5–29%)
Retinal hole	Sometimes (5–29%)
Rhegmatogenous retinal detachment	Sometimes (5–29%)
Shallow anterior chamber	Sometimes (5–29%)
Posterior vitreous detachment	Not recorded
Subcapsular cataract	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Avascular peripheral retina	Always
Abnormality of retina blood vessels	Very often (80–99%)
Retinal neovascularization	Often (30–79%)
Macular exudate	Sometimes (5–29%)
Macular telangiectasia	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low solidness and mass of the bones	Sometimes (5–29%)
Ectopic calcification	Rarely (1–4%)
Recurrent fractures	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability, mild	Sometimes (5–29%)
Mild global developmental delay	Sometimes (5–29%)
Motor delay	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bleeding from the eye	Sometimes (5–29%)
Vitreous hemorrhage	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Sometimes (5–29%)
Retinal arteriolar tortuosity	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature birth	Very often (80–99%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Small for gestational age	Very often (80–99%)

Laboratory abnormality

Trait	How often it is seen
Swelling caused by excess lymph fluid under skin	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FZD4 and how often each is seen. Find out more at hpo.jax.org.

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