Trait

Mental slowness

Clinical name: Abnormally slow thought process

An inner sense from the self that thoughts are abnormally slow and the individual feels that they are unable to increase their rate of thinking. The primary pathology is the decreased rate and other qualities of thinking (e.g. naming of objects) are intact, just slowed. This may be associated with slowed speech, but may be internal and masked by speech that is limited to brief (yes or no) answers.

HPO HP:0031843

Also called: Slowed thinking, Slowness of thought, Abnormally slow thought processes, Bradyphrenia, Slow thought processes, Slowed thoughts
Body system: Abnormality of the nervous system

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7 genes linked to Mental slowness

Changes in these genes cause rare conditions in which Mental slowness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
DMPKDM1 protein kinase	Very often (80–99%)	In 1 condition
HTThuntingtin	Often (30–79%)	In 1 condition
PRNPprion protein (Kanno blood group)	Often (30–79%)	In 1 condition
SLC2A3solute carrier family 2 member 3	Often (30–79%)	In 1 condition
CLTCclathrin heavy chain	Sometimes (5–29%)	In 1 condition
NOTCH3notch receptor 3	Sometimes (5–29%)	In 1 condition
VPS13Avacuolar protein sorting 13 homolog A	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Disordered formal thought process

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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