Gene
ASNS
asparagine synthetase (glutamine-hydrolyzing)
- HGNC 753(opens in a new tab)
- Ensembl gene ENSG00000070669(opens in a new tab)
- NCBI Gene 440(opens in a new tab)
Summary
- Cytogenetic location
- 7q21.3
- Coordinates
- Chromosome 7: 97,851,677–97,872,408 (GRCh38)
- Exons
- 13 exons across 20.7 kb
- Protein
- 561 amino acids
- MANE Select transcript
- ENST00000394308.8NM_001673.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads ASNS yet. The test sequences your whole genome, so your data includes it all the same.
How ASNS is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.4 kb of the gene's 20.7 kb; 1,686 of those bases code for the protein.
How a genome test reads ASNS
99
positions in ASNS where ClinVar classes a change as pathogenic or likely pathogenic
99 of them (100%) fall in regions short reads find hard.
- Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
- Segmental duplications (99 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.
A whole genome covers all 20.7 kb of ASNS, introns included, not only the 2.4 kb of exons.
Traits linked to ASNS
The Human Phenotype Ontology lists these as features of the rare conditions ASNS can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Cerebellar vermis hypoplasia
- Clonic seizure
- Dilated fourth ventricle
- Dilated third ventricle
- Epilepsy
- Generalized brain degeneration
- Global developmental delay
- Irritability
Show 21 more traits
- Pauses in breathing while sleeping
- Reduced cerebral white matter volume
- Severe global developmental delay
- Small brainstem
- Small cerebellum
- Tremor
- Ventriculomegaly
- Increased reflexes
- Caudate atrophy
- Clonus
- Exaggerated startle response
- Hypoplasia of the pons
- Hypsarrhythmia
- Simplified gyral pattern
- Thin corpus callosum
- Underdevelopment of part of brain called corpus callosum
- EEG with burst suppression
- Cortical dysplasia
- Delayed myelination
- Encephalopathy
- Profound global developmental delay
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ASNS gene: asparagine synthetase (glutamine-hydrolyzing). Retrieved 16 October 2026, from https://dantelabs.com/genes/asns
Dante Labs. ASNS gene: asparagine synthetase (glutamine-hydrolyzing) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/asns
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