Traits

Traits linked to MSH2

mutS homolog 2

The Human Phenotype Ontology links 68 traits to MSH2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Cât de frecvent apare
Glioblastoma multiforme	Foarte des (80–99%)
Anxiety	Des (30–79%)
Attention deficit	Des (30–79%)
Behavioral abnormality	Des (30–79%)
Depression	Des (30–79%)
Epilepsy	Des (30–79%)
Irritability	Des (30–79%)
Migraine	Des (30–79%)
Rise in pressure inside skull	Des (30–79%)
Abnormal gait	Uneori (5–29%)
Abnormal pyramidal sign	Uneori (5–29%)
Abnormal speech pattern	Uneori (5–29%)
Benign neoplasm of the central nervous system	Uneori (5–29%)
Cancer of early nerve cells	Uneori (5–29%)
Difficulty articulating speech	Uneori (5–29%)
Disorder of involuntary muscle movements	Uneori (5–29%)
Disturbed sensory perception	Uneori (5–29%)
Dysgraphia	Uneori (5–29%)
Hallucinations	Uneori (5–29%)
Loss of developmental milestones	Uneori (5–29%)
Memory impairment	Uneori (5–29%)
Paralysis or weakness of one side of body	Uneori (5–29%)
Pins and needles feeling	Uneori (5–29%)

Abnormality of the digestive system

Trait	Cât de frecvent apare
Abdominal pain	Foarte des (80–99%)
Constipation	Foarte des (80–99%)
Malabsorption	Foarte des (80–99%)
Colon cancer	Des (30–79%)
Nausea and vomiting	Des (30–79%)
Rectal tumor	Des (30–79%)
Stomach tumor	Des (30–79%)
Cancer of the pancreas	Uneori (5–29%)
Growths in inner lining of intestine	Uneori (5–29%)
Hepatocellular carcinoma	Uneori (5–29%)
Liver cancer	Uneori (5–29%)
Pancreatic adenocarcinoma	Uneori (5–29%)
Colonic diverticula	Neînregistrat
Duodenal adenocarcinoma	Neînregistrat
Hereditary nonpolyposis colorectal carcinoma	Neînregistrat
Non-cancerous GI tumors	Neînregistrat

Abnormality of the genitourinary system

Trait	Cât de frecvent apare
Ovarian cancer	Întotdeauna
Endometrial carcinoma	Uneori (5–29%)
Kidney cancer	Uneori (5–29%)
Malignant genitourinary tract tumor	Uneori (5–29%)
Urinary tract neoplasm	Uneori (5–29%)
Benign genitourinary tract neoplasm	Neînregistrat

Abnormality of the integument

Trait	Cât de frecvent apare
Sebaceous gland carcinoma	Întotdeauna
Skin cancer	Foarte des (80–99%)
Basal cell carcinoma	Uneori (5–29%)
Multiple birthmarks	Neînregistrat

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Low muscle tone	Des (30–79%)
Spasticity and rigidity of muscles	Des (30–79%)
Flexed joint that cannot be straightened	Uneori (5–29%)
Skeletal tumor	Uneori (5–29%)

Abnormality of blood and blood-forming tissues

Trait	Cât de frecvent apare
Gastrointestinal bleeding	Foarte des (80–99%)
Blood tumor	Uneori (5–29%)
T-cell acute lymphoblastic leukemias	Neînregistrat

Abnormality of the eye

Trait	Cât de frecvent apare
Amaurosis fugax	Uneori (5–29%)
Partial loss of field of vision	Uneori (5–29%)
Visual impairment	Uneori (5–29%)

Abnormality of head or neck

Trait	Cât de frecvent apare
Adenoma sebaceum	Foarte des (80–99%)
Cancer of salivary gland	Uneori (5–29%)

Abnormality of the endocrine system

Trait	Cât de frecvent apare
Neoplasm of the thyroid gland	Uneori (5–29%)
Noncancerous tumor in pituitary gland	Uneori (5–29%)

Abnormality of the breast

Trait	Cât de frecvent apare
Breast cancer	Uneori (5–29%)

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Cardiac diverticulum	Uneori (5–29%)

Abnormality of the respiratory system

Trait	Cât de frecvent apare
Laryngeal carcinoma	Uneori (5–29%)

Constitutional symptom

Trait	Cât de frecvent apare
Fatigue	Foarte des (80–99%)

Growth abnormality

Trait	Cât de frecvent apare
Weight loss	Foarte des (80–99%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MSH2 and how often each is seen. Find out more at hpo.jax.org.

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