Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
Traits
Traits linked to MSH2
mutS homolog 2
The Human Phenotype Ontology links 68 traits to MSH2, by body system: features seen in people with one of the gene's rare conditions.
Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
Abnormality of the nervous system
| Trait | How often it is seen |
|---|---|
| Glioblastoma multiforme | Very often (80–99%) |
| Anxiety | Often (30–79%) |
| Attention deficit | Often (30–79%) |
| Behavioral abnormality | Often (30–79%) |
| Depression | Often (30–79%) |
| Epilepsy | Often (30–79%) |
| Irritability | Often (30–79%) |
| Migraine | Often (30–79%) |
| Rise in pressure inside skull | Often (30–79%) |
| Abnormal gait | Sometimes (5–29%) |
| Abnormal pyramidal sign | Sometimes (5–29%) |
| Abnormal speech pattern | Sometimes (5–29%) |
| Benign neoplasm of the central nervous system | Sometimes (5–29%) |
| Cancer of early nerve cells | Sometimes (5–29%) |
| Difficulty articulating speech | Sometimes (5–29%) |
| Disorder of involuntary muscle movements | Sometimes (5–29%) |
| Disturbed sensory perception | Sometimes (5–29%) |
| Dysgraphia | Sometimes (5–29%) |
| Hallucinations | Sometimes (5–29%) |
| Loss of developmental milestones | Sometimes (5–29%) |
| Memory impairment | Sometimes (5–29%) |
| Paralysis or weakness of one side of body | Sometimes (5–29%) |
| Pins and needles feeling | Sometimes (5–29%) |
Abnormality of the digestive system
| Trait | How often it is seen |
|---|---|
| Abdominal pain | Very often (80–99%) |
| Constipation | Very often (80–99%) |
| Malabsorption | Very often (80–99%) |
| Colon cancer | Often (30–79%) |
| Nausea and vomiting | Often (30–79%) |
| Rectal tumor | Often (30–79%) |
| Stomach tumor | Often (30–79%) |
| Cancer of the pancreas | Sometimes (5–29%) |
| Growths in inner lining of intestine | Sometimes (5–29%) |
| Hepatocellular carcinoma | Sometimes (5–29%) |
| Liver cancer | Sometimes (5–29%) |
| Pancreatic adenocarcinoma | Sometimes (5–29%) |
| Colonic diverticula | Not recorded |
| Duodenal adenocarcinoma | Not recorded |
| Hereditary nonpolyposis colorectal carcinoma | Not recorded |
| Non-cancerous GI tumors | Not recorded |
Abnormality of the genitourinary system
| Trait | How often it is seen |
|---|---|
| Ovarian cancer | Always |
| Endometrial carcinoma | Sometimes (5–29%) |
| Kidney cancer | Sometimes (5–29%) |
| Malignant genitourinary tract tumor | Sometimes (5–29%) |
| Urinary tract neoplasm | Sometimes (5–29%) |
| Benign genitourinary tract neoplasm | Not recorded |
Abnormality of the integument
| Trait | How often it is seen |
|---|---|
| Sebaceous gland carcinoma | Always |
| Skin cancer | Very often (80–99%) |
| Basal cell carcinoma | Sometimes (5–29%) |
| Multiple birthmarks | Not recorded |
Abnormality of the musculoskeletal system
| Trait | How often it is seen |
|---|---|
| Low muscle tone | Often (30–79%) |
| Spasticity and rigidity of muscles | Often (30–79%) |
| Flexed joint that cannot be straightened | Sometimes (5–29%) |
| Skeletal tumor | Sometimes (5–29%) |
Abnormality of blood and blood-forming tissues
| Trait | How often it is seen |
|---|---|
| Gastrointestinal bleeding | Very often (80–99%) |
| Blood tumor | Sometimes (5–29%) |
| T-cell acute lymphoblastic leukemias | Not recorded |
Abnormality of the eye
| Trait | How often it is seen |
|---|---|
| Amaurosis fugax | Sometimes (5–29%) |
| Partial loss of field of vision | Sometimes (5–29%) |
| Visual impairment | Sometimes (5–29%) |
Abnormality of head or neck
| Trait | How often it is seen |
|---|---|
| Adenoma sebaceum | Very often (80–99%) |
| Cancer of salivary gland | Sometimes (5–29%) |
Abnormality of the endocrine system
| Trait | How often it is seen |
|---|---|
| Neoplasm of the thyroid gland | Sometimes (5–29%) |
| Noncancerous tumor in pituitary gland | Sometimes (5–29%) |
Abnormality of the breast
| Trait | How often it is seen |
|---|---|
| Breast cancer | Sometimes (5–29%) |
Abnormality of the cardiovascular system
| Trait | How often it is seen |
|---|---|
| Cardiac diverticulum | Sometimes (5–29%) |
Abnormality of the respiratory system
| Trait | How often it is seen |
|---|---|
| Laryngeal carcinoma | Sometimes (5–29%) |
Constitutional symptom
| Trait | How often it is seen |
|---|---|
| Fatigue | Very often (80–99%) |
Growth abnormality
| Trait | How often it is seen |
|---|---|
| Weight loss | Very often (80–99%) |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to MSH2 and how often each is seen. Find out more at hpo.jax.org.
Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks