Trait

Abnormal Descemet membrane morphology

Abnormality of Descemet's membrane, which is the basement membrane of the corneal endothelium.

HPO HP:0011490

Also called: Abnormality of Descemet's membrane
Body system: Abnormality of the eye

Read the genes linked to Abnormal Descemet membrane morphology, and the rest of your genome, with one test.

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12 genes linked to Abnormal Descemet membrane morphology

Changes in these genes cause rare conditions in which Abnormal Descemet membrane morphology is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AGBL1AGBL carboxypeptidase 1	Very often (80–99%)	In 1 condition
COL8A2collagen type VIII alpha 2 chain	Very often (80–99%)	In 2 conditions
GRHL2grainyhead like transcription factor 2	Very often (80–99%)	In 1 condition
OVOL2ovo like zinc finger 2	Very often (80–99%)	In 2 conditions
SLC4A11solute carrier family 4 member 11	Very often (80–99%)	In 3 conditions
TCF4transcription factor 4	Very often (80–99%)	In 1 condition
VSX1visual system homeobox 1	Very often (80–99%)	In 1 condition
ZEB1zinc finger E-box binding homeobox 1	Very often (80–99%)	In 3 conditions
CYP1B1cytochrome P450 family 1 subfamily B member 1	Often (30–79%)	In 2 conditions
LTBP2latent transforming growth factor beta binding protein 2	Often (30–79%)	In 1 condition
MYOCmyocilin	Often (30–79%)	In 1 condition
TEKTEK receptor tyrosine kinase	Often (30–79%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

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Broader traits

Abnormal corneal endothelium morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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