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Gene

SMPD2

sphingomyelin phosphodiesterase 2

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 109,440,724–109,443,919 (GRCh38)
Exons
10 exons across 3.2 kb
Protein
423 amino acids
Also known as
nSMase, ISC1
MANE Select transcript
ENST00000258052.8NM_003080.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SMPD2 yet. The test sequences your whole genome, so your data includes it all the same.

How SMPD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 6, with a bracket where SMPD2 sits. SMPD2 and 9 genes near it on chromosome 6, from 108,942,322 to 109,942,321.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27109 Mb109.2 Mb109.4 Mb109.6 Mb109.8 MbARMC2: 108,841,937–108,974,551, forward strandARMC2SESN1: 108,984,309–109,095,097, reverse strandSESN1CEP57L1: 109,095,105–109,174,418, forward strandCEP57L1CD164: 109,307,627–109,382,536, reverse strandCD164PPIL6: 109,390,215–109,441,171, reverse strandPPIL6SMPD2: 109,440,724–109,443,919, forward strandSMPD2MICAL1: 109,444,062–109,465,968, reverse strandMICAL1ZBTB24: 109,460,632–109,483,273, reverse strandZBTB24AK9: 109,492,855–109,691,229, reverse strandAK9FIG4: 109,690,609–109,878,098, forward strandFIG4Diagram of SMPD2: 10 exons on the forward strand of chromosome 6Exon 1: 109,440,724–109,441,171, 448 basesExon 2: 109,441,357–109,441,453, 97 basesExon 3: 109,441,552–109,441,628, 77 basesExon 4: 109,441,974–109,442,067, 94 basesExon 5: 109,442,210–109,442,299, 90 basesExon 6: 109,442,543–109,442,625, 83 basesExon 7: 109,442,752–109,442,884, 133 basesExon 8: 109,442,977–109,443,081, 105 basesExon 9: 109,443,267–109,443,420, 154 basesExon 10: 109,443,517–109,443,919, 403 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 3.2 kb; 1,272 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). SMPD2 gene: sphingomyelin phosphodiesterase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/smpd2

Vancouver

Dante Labs. SMPD2 gene: sphingomyelin phosphodiesterase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/smpd2

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