Trait

Recurrent Candida infection

Increased susceptibility to Candida infections as manifested by recurrent episodes of Candida infection.

HPO HP:0005401

Also called: Chronic candidiasis, Frequent candida infections, Persistent Candida infection, Recurrent candida infections, Recurrent candidiasis
Body system: Abnormality of the immune system

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20 genes linked to Recurrent Candida infection

Changes in these genes cause rare conditions in which Recurrent Candida infection is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AMOTL1angiomotin like 1	Always	In 1 condition
CD247CD247 molecule	Always	In 2 conditions
RFXAPregulatory factor X associated protein	Always	In 2 conditions
ZAP70zeta chain of T cell receptor associated protein kinase 70	Always	In 1 condition
DOCK8dedicator of cytokinesis 8	Very often (80–99%)	In 1 condition
CIITAclass II major histocompatibility complex transactivator	Often (30–79%)	In 1 condition
IL12RB1interleukin 12 receptor subunit beta 1	Often (30–79%)	In 1 condition
RFX5regulatory factor X5	Often (30–79%)	In 1 condition
RFXANKregulatory factor X associated ankyrin containing protein	Often (30–79%)	In 1 condition
BTDbiotinidase	Sometimes (5–29%)	In 1 condition
CD3DCD3 delta subunit of T-cell receptor complex	Sometimes (5–29%)	In 1 condition
CD3ECD3 epsilon subunit of T-cell receptor complex	Sometimes (5–29%)	In 1 condition
CTLA4cytotoxic T-lymphocyte associated protein 4	Sometimes (5–29%)	In 1 condition
FOXN1forkhead box N1	Sometimes (5–29%)	In 1 condition
GJB2gap junction protein beta 2	Sometimes (5–29%)	In 1 condition
GJB6gap junction protein beta 6	Sometimes (5–29%)	In 1 condition
IL7Rinterleukin 7 receptor	Sometimes (5–29%)	In 1 condition
PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Sometimes (5–29%)	In 1 condition
ZBTB24zinc finger and BTB domain containing 24	Sometimes (5–29%)	In 1 condition
SLC39A4solute carrier family 39 member 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Recurrent fungal infections Unusual Candida infection

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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