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Gene

SESN1

sestrin 1

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 108,984,309–109,094,846 (GRCh38)
Exons
10 exons across 110.5 kb
Protein
551 amino acids
Also known as
SEST1, PA26
MANE Select transcript
ENST00000436639.7NM_014454.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SESN1 yet. The test sequences your whole genome, so your data includes it all the same.

How SESN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where SESN1 sits. SESN1 and 9 genes near it on chromosome 6, from 108,539,578 to 109,539,577.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27108.6 Mb108.8 Mb109 Mb109.2 Mb109.4 MbFOXO3: 108,559,652–108,684,774, forward strandFOXO3ARMC2: 108,841,937–108,974,551, forward strandARMC2SESN1: 108,984,309–109,094,846, reverse strandSESN1CEP57L1: 109,095,105–109,174,418, forward strandCEP57L1CD164: 109,307,627–109,382,536, reverse strandCD164PPIL6: 109,390,215–109,441,171, reverse strandPPIL6SMPD2: 109,440,678–109,446,515, forward strandSMPD2MICAL1: 109,444,062–109,465,968, reverse strandMICAL1ZBTB24: 109,460,632–109,483,273, reverse strandZBTB24AK9: 109,492,855–109,691,229, reverse strandAK9Diagram of SESN1: 10 exons on the reverse strand of chromosome 6Exon 10: 108,984,309–108,987,630, 3,322 basesExon 9: 108,988,543–108,988,687, 145 basesExon 8: 108,990,645–108,990,835, 191 basesExon 7: 108,992,787–108,992,899, 113 basesExon 6: 108,994,462–108,994,609, 148 basesExon 5: 108,998,513–108,998,755, 243 basesExon 4: 109,000,491–109,000,673, 183 basesExon 3: 109,001,288–109,001,488, 201 basesExon 2: 109,002,278–109,002,343, 66 basesExon 1: 109,093,795–109,094,846, 1,052 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 110.5 kb; 1,656 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). SESN1 gene: sestrin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/sesn1

Vancouver

Dante Labs. SESN1 gene: sestrin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/sesn1

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