Traits

Traits linked to WNT10A

Wnt family member 10A

The Human Phenotype Ontology links 82 traits to WNT10A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Absence of adult teeth	Always
Failure of development of between one and six teeth	Always
Failure of development of more than six teeth	Always
Multiple eyelid margin cysts	Always
Wide gaps between baby teeth	Always
Chewing difficulties	Very often (80–99%)
Decreased size of teeth	Very often (80–99%)
Early loss of baby teeth	Very often (80–99%)
Abnormality of baby teeth	Often (30–79%)
Abnormality of dental shape	Often (30–79%)
Absence of premolar	Often (30–79%)
Absence of six year molar	Often (30–79%)
Absence of upper lateral incisor	Often (30–79%)
Absent central incisor	Often (30–79%)
Bad bite	Often (30–79%)
Cone shaped front tooth	Often (30–79%)
Decreased length of dental roots	Often (30–79%)
Decreased size of tooth	Often (30–79%)
Delayed eruption of permanent teeth	Often (30–79%)
Delayed eruption of teeth	Often (30–79%)
Short eyelashes	Often (30–79%)
Smooth tongue	Often (30–79%)
Sparse eyebrow	Often (30–79%)
Sparse or absent eyebrows	Often (30–79%)
Sparse scalp hair	Often (30–79%)
Widely spaced teeth	Often (30–79%)
Abnormality of canine	Sometimes (5–29%)
Abnormality of shape of baby molar	Sometimes (5–29%)
Absence of lower premolar	Sometimes (5–29%)
Bird-like facial appearance	Sometimes (5–29%)
Cleft of the mouth	Sometimes (5–29%)
Outward turned lips	Sometimes (5–29%)
Peg-shaped maxillary lateral incisors	Sometimes (5–29%)
Short face	Sometimes (5–29%)
Taurodontia	Sometimes (5–29%)
Thin dental enamel	Sometimes (5–29%)
Decreased number of teeth	Not recorded

Abnormality of the integument

Trait	How often it is seen
Dry skin	Always
Hyperkeratosis	Always
Poor fingernail formation	Always
Poor nail formation	Always
Short nail	Always
Sparse body hair	Always
Sparse hair	Always
Abnormal fingernails	Very often (80–99%)
Abnormality of the hair	Very often (80–99%)
Abnormality of the toenail	Very often (80–99%)
Ectodermal dysplasia	Very often (80–99%)
Fine hair	Very often (80–99%)
Decreased ability to sweat	Often (30–79%)
Follicular hyperkeratosis	Often (30–79%)
Grooved nails	Often (30–79%)
Hair loss	Often (30–79%)
Poor toenail formation	Often (30–79%)
Thin nail	Often (30–79%)
Basal cell carcinoma	Sometimes (5–29%)
Excessive sweating	Sometimes (5–29%)
Squamous cell carcinoma	Sometimes (5–29%)
Thin skin	Sometimes (5–29%)
Absent nails	Not recorded
Apocrine hidrocystoma	Not recorded
Atypical nail growth	Not recorded
Chicken skin	Not recorded
Detachment of nail	Not recorded
Dry hair	Not recorded
Hypergranulosis	Not recorded
Narrow nail	Not recorded
Orthokeratosis	Not recorded
Poroma	Not recorded
Small nail	Not recorded
Thickening of upper layer of skin	Not recorded

Abnormality of limbs

Trait	How often it is seen
Thickening of palms and soles	Always
Excessive sweating of palms and soles	Often (30–79%)
Plantar hyperkeratosis	Often (30–79%)
Thickening of the outer layer of the skin of the palms and soles	Often (30–79%)
Palmar hyperkeratosis	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Facial telangiectasia	Very often (80–99%)
Palmoplantar erythema	Often (30–79%)
Redness of skin or mucous membrane	Not recorded

Abnormality of the eye

Trait	How often it is seen
Extreme sensitivity of the eyes to light	Often (30–79%)
Abnormality of the eye	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Ovarian cancer	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WNT10A and how often each is seen. Find out more at hpo.jax.org.

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