Traits

Traits linked to TRA2B

transformer 2 beta homolog

The Human Phenotype Ontology links 63 traits to TRA2B, by body system: features seen in people with one of the gene's rare conditions.

TRA2B

Abnormality of the nervous system

Trait	How often it is seen
Delayed ability to walk	Always
Delayed speech and language development	Always
Difficulty staying asleep	Always
Inability to coordinate movements when walking	Always
Intellectual disability	Always
Moderate global developmental delay	Always
Profound global developmental delay	Always
Severe global developmental delay	Always
Difficulty sleeping	Often (30–79%)
Generalized brain degeneration	Often (30–79%)
Hypsarrhythmia	Often (30–79%)
Infantile spasms	Often (30–79%)
Interictal EEG abnormality	Often (30–79%)
Thin corpus callosum	Often (30–79%)
Ventriculomegaly	Often (30–79%)
Aggressive behavior	Sometimes (5–29%)
Autism spectrum disorder	Sometimes (5–29%)
Cortical dysplasia	Sometimes (5–29%)
Delayed CNS myelination	Sometimes (5–29%)
Epileptic encephalopathy	Sometimes (5–29%)
Low frustration tolerance	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)
Small cerebellum	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Webbed 2nd and 3rd toes	Always
Curvature of little finger	Often (30–79%)
Short fingers or toes	Often (30–79%)
Dropped arches	Sometimes (5–29%)
Slender finger	Sometimes (5–29%)
Tapered finger	Sometimes (5–29%)
Webbed fingers or toes	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Always
Low muscle tone in trunk	Always
Lumbar scoliosis	Always
Scoliosis	Always
Thoracic kyphosis	Always
Low muscle tone	Very often (80–99%)

Abnormality of the eye

Trait	How often it is seen
Cerebral visual impairment	Often (30–79%)
Astigmatism	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Outward facing eye ball	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally large tongue	Always
High forehead	Always
Wide mouth	Always
Abnormally small head	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of lung artery	Always
Narrowing of pulmonic valve	Sometimes (5–29%)
Patent ductus arteriosus	Sometimes (5–29%)
Patent foramen ovale	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic constipation	Often (30–79%)
Feeding difficulties	Often (30–79%)
Acid reflux	Sometimes (5–29%)
Poor swallowing	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Obesity	Always
Decreased body weight	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Fetal pericardial effusion	Always
Low levels of amniotic fluid	Always

Abnormality of the endocrine system

Trait	How often it is seen
Delayed puberty	Always
Reduced circulating growth hormone concentration	Always

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Increased calcium level in kidney	Always

Abnormality of the integument

Trait	How often it is seen
Patchy baldness	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRA2B and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test