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Gene

THBS1

thrombospondin 1

Summary

Cytogenetic location
15q14
Coordinates
Chromosome 15: 39,581,079–39,599,466 (GRCh38)
Exons
22 exons across 18.4 kb
Protein
1,170 amino acids
Also known as
TSP1, THBS, TSP, THBS-1, TSP-1
MANE Select transcript
ENST00000260356.6NM_003246.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Glaucoma

    • Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

      • 1 GenCC submitter rates it definitive or strong
      Actionability

      IOP-lowering drops (prostaglandin analogs, beta-blockers); selective laser trabeculoplasty; MIGS surgery; trabeculotomy/goniotomy for congenital glaucoma; cascade family genetic testing; annual IOP monitoring for carriers

How THBS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 15, with a bracket where THBS1 sits. THBS1 and 5 genes near it on chromosome 15, from 39,090,273 to 40,090,272.Chromosome 1515q14p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.339.2 Mb39.4 Mb39.6 Mb39.8 Mb40 MbTHBS1: 39,581,079–39,599,466, forward strandTHBS1FSIP1: 39,588,357–39,782,858, reverse strandFSIP1GPR176: 39,799,003–39,920,976, reverse strandGPR176EIF2AK4: 39,934,062–40,036,656, forward strandEIF2AK4SRP14: 40,032,985–40,039,186, reverse strandSRP14BMF: 40,087,889–40,108,928, reverse strandBMFDiagram of THBS1: 22 exons on the forward strand of chromosome 15Exon 1: 39,581,079–39,581,228, 150 basesExon 2: 39,581,829–39,581,924, 96 basesExon 3: 39,582,193–39,582,752, 560 basesExon 4: 39,583,617–39,583,692, 76 basesExon 5: 39,583,988–39,584,187, 200 basesExon 6: 39,584,300–39,584,422, 123 basesExon 7: 39,585,470–39,585,563, 94 basesExon 8: 39,587,347–39,587,520, 174 basesExon 9: 39,588,042–39,588,218, 177 basesExon 10: 39,588,526–39,588,699, 174 basesExon 11: 39,588,959–39,589,086, 128 basesExon 12: 39,589,202–39,589,354, 153 basesExon 13: 39,589,805–39,590,023, 219 basesExon 14: 39,590,516–39,590,623, 108 basesExon 15: 39,591,191–39,591,350, 160 basesExon 16: 39,591,505–39,591,623, 119 basesExon 17: 39,592,568–39,592,802, 235 basesExon 18: 39,593,000–39,593,227, 228 basesExon 19: 39,593,397–39,593,668, 272 basesExon 20: 39,594,099–39,594,196, 98 basesExon 21: 39,594,301–39,594,440, 140 basesExon 22: 39,595,362–39,599,466, 4,105 bases12468101214161820225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 18.4 kb; 3,513 of those bases code for the protein.

Genes linked to the same conditions

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). THBS1 gene: thrombospondin 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/thbs1

Vancouver

Dante Labs. THBS1 gene: thrombospondin 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/thbs1

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