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Gene

IKZF3

IKAROS family zinc finger 3

Summary

Cytogenetic location
17q12-q21.1
Coordinates
Chromosome 17: 39,757,718–39,864,312 (GRCh38)
Exons
8 exons across 106.6 kb
Protein
509 amino acids
Also known as
Aiolos
Previous symbols
ZNFN1A3
MANE Select transcript
ENST00000346872.8NM_012481.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • ClinGen rates the link moderate
        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How IKZF3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 17, with a bracket where IKZF3 sits. IKZF3 and 28 genes near it on chromosome 17, from 39,311,015 to 40,311,014.Chromosome 1717q12-q21.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.339.4 Mb39.6 Mb39.8 Mb40 Mb40.2 MbFBXL20: 39,252,663–39,402,523, reverse strandFBXL20MED1: 39,404,253–39,451,306, reverse strandMED1CDK12: 39,461,437–39,567,559, forward strandCDK12NEUROD2: 39,603,536–39,609,777, reverse strandNEUROD2PPP1R1B: 39,626,740–39,636,626, forward strandSTARD3: 39,637,058–39,664,201, forward strandSTARD3TCAP: 39,664,990–39,666,554, forward strandTCAPPNMT: 39,667,981–39,670,484, forward strandPNMTPGAP3: 39,671,120–39,696,797, reverse strandPGAP3ERBB2: 39,687,914–39,730,426, forward strandERBB2MIEN1: 39,728,496–39,730,555, reverse strandMIEN1GRB7: 39,737,490–39,747,292, forward strandGRB7IKZF3: 39,757,718–39,864,312, reverse strandIKZF3ZPBP2: 39,868,202–39,877,896, forward strandZPBP2GSDMB: 39,904,595–39,919,854, reverse strandGSDMBORMDL3: 39,919,927–39,982,186, reverse strandORMDL3LRRC3C: 39,927,725–39,946,538, forward strandLRRC3CGSDMA: 39,953,263–39,977,875, forward strandGSDMAPSMD3: 39,980,800–39,997,960, forward strandPSMD3CSF3: 40,015,361–40,017,816, forward strandCSF3MED24: 40,019,097–40,061,215, reverse strandMED24THRA: 40,058,290–40,093,867, forward strandTHRANR1D1: 40,092,793–40,100,630, reverse strandNR1D1MSL1: 40,121,637–40,136,935, forward strandMSL1CASC3: 40,140,278–40,177,001, forward strandCASC3RAPGEFL1: 40,177,010–40,195,656, forward strandRAPGEFL1WIPF2: 40,218,743–40,284,136, forward strandWIPF2CDC6: 40,287,831–40,304,657, forward strandCDC6RARA: 40,309,165–40,357,643, forward strandRARADiagram of IKZF3: 8 exons on the reverse strand of chromosome 17Exon 8: 39,757,718–39,766,493, 8,776 basesExon 7: 39,777,651–39,777,767, 117 basesExon 6: 39,788,258–39,788,374, 117 basesExon 5: 39,791,416–39,791,583, 168 basesExon 4: 39,792,673–39,792,933, 261 basesExon 3: 39,829,387–39,829,488, 102 basesExon 2: 39,832,098–39,832,151, 54 basesExon 1: 39,864,120–39,864,312, 193 bases864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9.8 kb of the gene's 106.6 kb; 1,530 of those bases code for the protein.

    How a genome test reads IKZF3

    1

    position in IKZF3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 106.6 kb of IKZF3, introns included, not only the 9.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). IKZF3 gene: IKAROS family zinc finger 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/ikzf3

    Vancouver

    Dante Labs. IKZF3 gene: IKAROS family zinc finger 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ikzf3

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