Traits

Traits linked to SCARF2

scavenger receptor class F member 2

The Human Phenotype Ontology links 76 traits to SCARF2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Bunion	Always
Camptodactyly of 2nd-5th fingers	Always
Distal ulnar hypoplasia	Always
Dropped arches	Always
Elbow flexion contracture	Always
Knock knees	Always
Long big toe	Always
Radioulnar subluxation	Always
Recurrent patellar dislocation	Always
Tapered finger	Always
Webbed skin of 2nd-3rd toes	Always
Long slender fingers	Very often (80–99%)
Bowing of the long bones	Often (30–79%)
Dislocated radial head	Often (30–79%)
Long foot	Often (30–79%)
Slender long bones of hand	Often (30–79%)
Webbed 2nd and 3rd toes	Often (30–79%)
Club feet	Sometimes (5–29%)
Curvature of digit	Sometimes (5–29%)
Knee contracture	Sometimes (5–29%)
Bowed thighbone	Not recorded
Camptodactyly of toe	Not recorded
Curving of inner forearm bone	Not recorded
Elongated long bone of hand	Not recorded
Inability to straighten knee	Not recorded
Joint contracture of the hand	Not recorded
Narrow foot	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Beaked nose	Always
Decreased size of maxilla	Always
Depressed nasal bridge	Always
Drooping lower lip	Always
High palate	Always
High, narrow palate	Always
Little lower jaw	Always
Narrow mouth	Always
Narrow nose	Always
Narrow opening between the eyelids	Always
Scaphocephaly	Always
Triangular face	Always
Zygomatic flattening	Very often (80–99%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Facial asymmetry	Often (30–79%)
Abnormal columella morphology	Sometimes (5–29%)
Deformity of the skull	Sometimes (5–29%)
Dental crowding	Sometimes (5–29%)
Deviated nasal septum	Sometimes (5–29%)
Underdeveloped tissue around nostril	Sometimes (5–29%)
Abnormality of the eyebrow	Not recorded
Cleft palate	Not recorded
Narrowing of the rear opening of the nasal cavity	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Always
Elbow contracture	Always
Hook-shaped collarbone	Always
Permanent flexion of the finger or toe	Always
Joint contracture	Often (30–79%)
Thin ribs	Often (30–79%)
Glenoid fossa hypoplasia	Sometimes (5–29%)
Short collarbone	Sometimes (5–29%)
Short ribs	Sometimes (5–29%)
Small shoulder blade	Sometimes (5–29%)
Funnel chest	Not recorded
Slender long bone	Not recorded

Abnormality of the ear

Trait	How often it is seen
Small earlobe	Always
Ears rotated toward back of head	Often (30–79%)
Overfolded ears	Often (30–79%)
Prominent ear	Often (30–79%)
Hearing impairment	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Abnormal aryepiglottic fold morphology	Sometimes (5–29%)
Noisy breathing	Not recorded
Softening of voice box tissue	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Dilatation of the renal pelvis	Sometimes (5–29%)
Hydronephrosis	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Only one artery in umbilical cord instead of two	Not recorded

Abnormality of the eye

Trait	How often it is seen
Hardening of skin and connective tissue	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Spinal dimple	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SCARF2 and how often each is seen. Find out more at hpo.jax.org.

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