Traits

Traits linked to NFKB2

nuclear factor kappa B subunit 2

The Human Phenotype Ontology links 55 traits to NFKB2, by body system: features seen in people with one of the gene's rare conditions.

NFKB2

Abnormality of the immune system

Trait	How often it is seen
Asthma	Always
Combined immunodeficiency	Always
Recurrent bronchitis	Very often (80–99%)
Recurrent pneumonia	Very often (80–99%)
Recurrent viral infections	Very often (80–99%)
Anti-thyroid peroxidase antibody positivity	Often (30–79%)
Recurrent oral herpes	Often (30–79%)
Anti-thyroglobulin antibody positivity	Sometimes (5–29%)
Infection in blood stream	Sometimes (5–29%)
Psoriasiform dermatitis	Sometimes (5–29%)
Unusual fungal nail infection	Sometimes (5–29%)
Autoimmune antibody positivity	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Abnormal response to ACTH stimulation test	Always
Central adrenal insufficiency	Always
Adrenocorticotropin deficient adrenal insufficiency	Very often (80–99%)
Decreased circulating ACTH concentration	Very often (80–99%)
Low blood cortisol level	Very often (80–99%)
Abnormal size of pituitary gland	Often (30–79%)
Decreased circulating androgen concentration	Sometimes (5–29%)
Decreased circulating insulin-like growth factor 1 concentration	Sometimes (5–29%)
Decreased response to growth hormone stimulation test	Sometimes (5–29%)
Thyroid gland inflammation	Not recorded

Abnormality of the integument

Trait	How often it is seen
Abnormal periungual morphology	Often (30–79%)
Alopecia totalis	Often (30–79%)
Hair loss	Often (30–79%)
Poor nail formation	Often (30–79%)
Trachyonychia	Often (30–79%)
Blotchy loss of skin color	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating IgA concentration	Always
Decreased circulating IgG concentration	Always
Decreased circulating IgM concentration	Always
Decreased circulating antibody level	Very often (80–99%)

Abnormality of head or neck

Trait	How often it is seen
Recurrent viral upper respiratory tract infections	Always
Recurrent colds	Very often (80–99%)
Recurrent sinus disease	Very often (80–99%)
Recurrent sore throat	Very often (80–99%)

Abnormality of the nervous system

Trait	How often it is seen
Coma caused by low blood sugar	Very often (80–99%)
Chiari type I malformation	Often (30–79%)
Brief seizures with staring spells	Sometimes (5–29%)
Global developmental delay	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Low blood sodium levels	Very often (80–99%)
Recurrent low blood sugar levels	Very often (80–99%)
Increased circulating potassium concentration	Not recorded
Low blood sugar	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low B cell count	Very often (80–99%)
Abnormal lymphocyte morphology	Often (30–79%)
Autoimmune thrombocytopenia	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Frequent Giardia lamblia infestation	Often (30–79%)
Pyloric stenosis	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Low blood pressure	Very often (80–99%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Very often (80–99%)

Abnormality of the eye

Trait	How often it is seen
Double vision	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NFKB2 and how often each is seen. Find out more at hpo.jax.org.

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