Trait

Decreased hemoglobin concentration

An abnormal reduction below normal hemoglobin concentration in the circulation.

HPO HP:0020062

Also called: Decreased haemoglobin concentration, Decreased Hb concentration
Body system: Abnormality of blood and blood-forming tissues

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6 genes linked to Decreased hemoglobin concentration

Changes in these genes cause rare conditions in which Decreased hemoglobin concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
KLF1KLF transcription factor 1	Always	In 1 condition
OAS22'-5'-oligoadenylate synthetase 2	Always	In 1 condition
PKLRpyruvate kinase L/R	Always	In 1 condition
RBSNrabenosyn, RAB effector	Always	In 1 condition
MADDMAP kinase activating death domain	Very often (80–99%)	In 2 conditions
PGK1phosphoglycerate kinase 1	Often (30–79%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal hemoglobin concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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