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Gene

IL1B

interleukin 1 beta

Summary

Cytogenetic location
2q14.1
Coordinates
Chromosome 2: 112,829,751–112,836,779 (GRCh38)
Exons
7 exons across 7 kb
Protein
269 amino acids
Also known as
IL1F2, IL-1B, IL1-BETA
MANE Select transcript
ENST00000263341.7NM_000576.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads IL1B yet. The test sequences your whole genome, so your data includes it all the same.

How IL1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 2, with a bracket where IL1B sits. IL1B and 18 genes near it on chromosome 2, from 112,333,265 to 113,333,264.Chromosome 22q14.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3112.4 Mb112.6 Mb112.8 Mb113 Mb113.2 MbZC3H6: 112,275,565–112,340,059, forward strandZC3H6RGPD8: 112,368,369–112,434,488, reverse strandRGPD8TTL: 112,482,112–112,541,739, forward strandTTLPOLR1B: 112,541,915–112,579,818, forward strandPOLR1BCHCHD5: 112,584,240–112,589,275, forward strandCHCHD5SLC20A1: 112,645,853–112,664,727, forward strandSLC20A1NT5DC4: 112,721,020–112,742,879, forward strandNT5DC4CKAP2L: 112,736,349–112,764,664, reverse strandCKAP2LIL1A: 112,773,916–112,784,500, reverse strandIL1AIL1B: 112,829,751–112,836,779, reverse strandIL1BIL37: 112,911,160–112,918,882, forward strandIL37IL36G: 112,973,203–112,985,672, forward strandIL36GIL36A: 113,005,459–113,008,044, forward strandIL36AIL36B: 113,022,089–113,052,867, reverse strandIL36BIL36RN: 113,058,638–113,065,382, forward strandIL36RNIL38: 113,067,970–113,075,843, forward strandIL38IL1RN: 113,099,315–113,134,016, forward strandIL1RNPSD4: 113,157,325–113,209,396, forward strandPSD4PAX8: 113,215,997–113,279,001, reverse strandPAX8Diagram of IL1B: 7 exons on the reverse strand of chromosome 2Exon 7: 112,829,751–112,830,573, 823 basesExon 6: 112,831,292–112,831,422, 131 basesExon 5: 112,832,662–112,832,826, 165 basesExon 4: 112,833,374–112,833,575, 202 basesExon 3: 112,835,566–112,835,617, 52 basesExon 2: 112,836,183–112,836,244, 62 basesExon 1: 112,836,708–112,836,779, 72 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 7 kb; 810 of those bases code for the protein.

Traits linked to IL1B

The Human Phenotype Ontology lists these as features of the rare conditions IL1B can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). IL1B gene: interleukin 1 beta. Retrieved 18 October 2026, from https://dantelabs.com/genes/il1b

Vancouver

Dante Labs. IL1B gene: interleukin 1 beta [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/il1b

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