Traits

Traits linked to DNAJC6

DnaJ heat shock protein family (Hsp40) member C6

The Human Phenotype Ontology links 64 traits to DNAJC6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Balance impairment	Always
Difficulty articulating speech	Always
Glabellar reflex	Always
Loss of ability to walk	Always
Pill-rolling tremor	Always
Slow movements	Always
Dystonia	Very often (80–99%)
Inability to walk	Very often (80–99%)
Resting tremor	Very often (80–99%)
Slowed slurred speech	Very often (80–99%)
Abnormal nervous system physiology	Often (30–79%)
Abnormal pyramidal sign	Often (30–79%)
Abnormality of movement	Often (30–79%)
Akinesia	Often (30–79%)
Brain degeneration	Often (30–79%)
Decreased reflex response	Often (30–79%)
Depression	Often (30–79%)
Disorder of involuntary muscle movements	Often (30–79%)
Epilepsy	Often (30–79%)
Hallucinations	Often (30–79%)
Inability to coordinate movements when walking	Often (30–79%)
Intellectual disability	Often (30–79%)
Involuntary movements	Often (30–79%)
Lack of feeling, emotion, interest	Often (30–79%)
Short stepped shuffling walk	Often (30–79%)
Tremor	Often (30–79%)
Abnormal autonomic nervous system physiology	Sometimes (5–29%)
Abnormality of balance	Sometimes (5–29%)
Anxiety	Sometimes (5–29%)
Cognitive impairment	Sometimes (5–29%)
Dementia	Sometimes (5–29%)
Difficulty staying or falling asleep	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Jerking	Sometimes (5–29%)
Loss of articulate speech	Sometimes (5–29%)
Panic attack	Sometimes (5–29%)
Poor social interactions	Sometimes (5–29%)
Short attention span	Sometimes (5–29%)
Shuffled walk	Sometimes (5–29%)
Willis-Ekbom disease	Sometimes (5–29%)
Agitation	Rarely (1–4%)
Frontal lobe dementia	Rarely (1–4%)
Impulsivity	Rarely (1–4%)
Parkinsonism	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Sometimes (5–29%)
Delayed gastric emptying	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Nausea	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Rigidity	Very often (80–99%)
Scoliosis	Often (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Sometimes (5–29%)
Muscle spasm	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Increased muscle tone of arm or leg	Always
High-arched foot	Often (30–79%)
Leg muscle stiffness	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Hypometric saccades	Often (30–79%)
Abnormal color vision	Sometimes (5–29%)
Double vision	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Decreased facial expressions	Always
Hyposmia	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Female sexual dysfunction	Sometimes (5–29%)
Male sexual dysfunction	Sometimes (5–29%)

Abnormality of the voice

Trait	How often it is seen
Weak voice	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DNAJC6 and how often each is seen. Find out more at hpo.jax.org.

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