Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

MANF

mesencephalic astrocyte derived neurotrophic factor

Summary

Cytogenetic location
3p21.2
Coordinates
Chromosome 3: 51,385,291–51,389,397 (GRCh38)
Exons
4 exons across 4.1 kb
Protein
182 amino acids
Also known as
ARP
Previous symbols
ARMET
MANE Select transcript
ENST00000528157.7NM_006010.6
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads MANF yet. The test sequences your whole genome, so your data includes it all the same.

How MANF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 3, with a bracket where MANF sits. MANF and 12 genes near it on chromosome 3, from 50,887,344 to 51,887,343.Chromosome 33p21.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2951 Mb51.2 Mb51.4 Mb51.6 Mb51.8 MbDOCK3: 50,674,875–51,384,198, forward strandDOCK3MANF: 51,385,291–51,389,397, forward strandMANFRBM15B: 51,391,285–51,397,908, forward strandRBM15BDCAF1: 51,395,867–51,500,097, reverse strandDCAF1RAD54L2: 51,538,666–51,668,667, forward strandRAD54L2TEX264: 51,662,693–51,704,323, forward strandTEX264GRM2: 51,707,057–51,718,616, forward strandGRM2IQCF6: 51,778,561–51,779,241, reverse strandIQCF6: 51,798,803–51,830,856, forward strandIQCF1: 51,809,295–51,903,369, reverse strandIQCF1IQCF3: 51,826,883–51,833,389, forward strandIQCF3IQCF2: 51,861,615–51,863,424, forward strandIQCF2IQCF5: 51,873,721–51,875,601, reverse strandIQCF5Diagram of MANF: 4 exons on the forward strand of chromosome 3Exon 1: 1 known disease-causing siteExon 1: 51,385,291–51,385,436, 146 basesExon 2: 51,386,208–51,386,335, 128 basesExon 3: 51,387,737–51,387,878, 142 basesExon 4: 51,388,905–51,389,397, 493 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 4.1 kb; 549 of those bases code for the protein.

Sequencing MANF

1

position in MANF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.1 kb of MANF, introns included, not only the 0.9 kb of exons.

Traits linked to MANF

The Human Phenotype Ontology lists these as features of the rare conditions MANF can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). MANF gene: mesencephalic astrocyte derived neurotrophic factor. Retrieved 17 October 2026, from https://dantelabs.com/genes/manf

Vancouver

Dante Labs. MANF gene: mesencephalic astrocyte derived neurotrophic factor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/manf

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test