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Gene

ITGB6

integrin subunit beta 6

Summary

Cytogenetic location
2q24.2
Coordinates
Chromosome 2: 160,099,671–160,200,272 (GRCh38)
Exons
15 exons across 100.6 kb
Protein
788 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000283249.7NM_000888.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ITGB6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where ITGB6 sits. ITGB6 and 6 genes near it on chromosome 2, from 159,649,972 to 160,649,971.Chromosome 22q24.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3159.8 Mb160 Mb160.2 Mb160.4 Mb160.6 MbMARCHF7: 159,712,001–159,800,960, forward strandMARCHF7CD302: 159,764,912–159,798,389, reverse strandCD302LY75-CD302: 159,771,851–159,904,710, reverse strandLY75-CD302LY75: 159,803,344–159,904,847, reverse strandLY75PLA2R1: 159,932,006–160,062,906, reverse strandPLA2R1ITGB6: 160,099,671–160,200,272, reverse strandITGB6RBMS1: 160,272,151–160,494,100, reverse strandRBMS1Diagram of ITGB6: 15 exons on the reverse strand of chromosome 2Exon 8: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 15: 160,099,671–160,101,834, 2,164 basesExon 14: 160,107,679–160,107,845, 167 basesExon 13: 160,112,080–160,112,199, 120 basesExon 12: 160,123,791–160,123,888, 98 basesExon 11: 160,126,379–160,126,601, 223 basesExon 10: 160,137,434–160,137,851, 418 basesExon 9: 160,138,065–160,138,199, 135 basesExon 8: 160,141,982–160,142,071, 90 basesExon 7: 160,169,212–160,169,307, 96 basesExon 6: 160,172,569–160,172,730, 162 basesExon 5: 160,173,974–160,174,139, 166 basesExon 4: 160,195,369–160,195,615, 247 basesExon 3: 160,196,216–160,196,420, 205 basesExon 2: 160,199,179–160,199,258, 80 basesExon 1: 160,200,003–160,200,272, 270 bases1510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 100.6 kb; 2,367 of those bases code for the protein.

How a genome test reads ITGB6

7

positions in ITGB6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 100.6 kb of ITGB6, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITGB6 gene: integrin subunit beta 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/itgb6

Vancouver

Dante Labs. ITGB6 gene: integrin subunit beta 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/itgb6

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