{
  "url": "https://dantelabs.com/traits/facial-diplegia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "facial-diplegia",
    "id": "HP:0001349",
    "name": "Facial diplegia",
    "definition": "Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy).",
    "synonyms": [
      "Bilateral facial weakness",
      "Facial paresis, bilateral"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "facial-palsy",
        "name": "Bell's palsy",
        "url": "https://dantelabs.com/traits/facial-palsy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "adcy6",
        "symbol": "ADCY6",
        "hgnc": "HGNC:237",
        "name": "adenylate cyclase 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adcy6"
      },
      {
        "slug": "jph1",
        "symbol": "JPH1",
        "hgnc": "HGNC:14201",
        "name": "junctophilin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph1"
      },
      {
        "slug": "mpz",
        "symbol": "MPZ",
        "hgnc": "HGNC:7225",
        "name": "myelin protein zero",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpz"
      },
      {
        "slug": "mtrfr",
        "symbol": "MTRFR",
        "hgnc": "HGNC:26784",
        "name": "mitochondrial translation release factor in rescue",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mtrfr"
      },
      {
        "slug": "cntnap1",
        "symbol": "CNTNAP1",
        "hgnc": "HGNC:8011",
        "name": "contactin associated protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cntnap1"
      },
      {
        "slug": "crppa",
        "symbol": "CRPPA",
        "hgnc": "HGNC:37276",
        "name": "CDP-L-ribitol pyrophosphorylase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crppa"
      },
      {
        "slug": "fkrp",
        "symbol": "FKRP",
        "hgnc": "HGNC:17997",
        "name": "fukutin related protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkrp"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "pomt1",
        "symbol": "POMT1",
        "hgnc": "HGNC:9202",
        "name": "protein O-mannosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomt1"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "slc12a6",
        "symbol": "SLC12A6",
        "hgnc": "HGNC:10914",
        "name": "solute carrier family 12 member 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a6"
      },
      {
        "slug": "yme1l1",
        "symbol": "YME1L1",
        "hgnc": "HGNC:12843",
        "name": "YME1 like 1 ATPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yme1l1"
      },
      {
        "slug": "abca1",
        "symbol": "ABCA1",
        "hgnc": "HGNC:29",
        "name": "ATP binding cassette subfamily A member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abca1"
      },
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "adgrg1",
        "symbol": "ADGRG1",
        "hgnc": "HGNC:4512",
        "name": "adhesion G protein-coupled receptor G1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrg1"
      },
      {
        "slug": "bin1",
        "symbol": "BIN1",
        "hgnc": "HGNC:1052",
        "name": "bridging integrator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bin1"
      },
      {
        "slug": "cfl2",
        "symbol": "CFL2",
        "hgnc": "HGNC:1875",
        "name": "cofilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfl2"
      },
      {
        "slug": "cryab",
        "symbol": "CRYAB",
        "hgnc": "HGNC:2389",
        "name": "crystallin alpha B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryab"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "kbtbd13",
        "symbol": "KBTBD13",
        "hgnc": "HGNC:37227",
        "name": "kelch repeat and BTB domain containing 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kbtbd13"
      },
      {
        "slug": "klhl40",
        "symbol": "KLHL40",
        "hgnc": "HGNC:30372",
        "name": "kelch like family member 40",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl40"
      },
      {
        "slug": "klhl41",
        "symbol": "KLHL41",
        "hgnc": "HGNC:16905",
        "name": "kelch like family member 41",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/klhl41"
      },
      {
        "slug": "lmod3",
        "symbol": "LMOD3",
        "hgnc": "HGNC:6649",
        "name": "leiomodin 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmod3"
      },
      {
        "slug": "mypn",
        "symbol": "MYPN",
        "hgnc": "HGNC:23246",
        "name": "myopalladin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mypn"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "pi4ka",
        "symbol": "PI4KA",
        "hgnc": "HGNC:8983",
        "name": "phosphatidylinositol 4-kinase alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pi4ka"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "shmt2",
        "symbol": "SHMT2",
        "hgnc": "HGNC:10852",
        "name": "serine hydroxymethyltransferase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shmt2"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "speg",
        "symbol": "SPEG",
        "hgnc": "HGNC:16901",
        "name": "striated muscle enriched protein kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/speg"
      },
      {
        "slug": "srpx2",
        "symbol": "SRPX2",
        "hgnc": "HGNC:30668",
        "name": "sushi repeat containing protein X-linked 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srpx2"
      },
      {
        "slug": "tpm2",
        "symbol": "TPM2",
        "hgnc": "HGNC:12011",
        "name": "tropomyosin 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tpm2"
      },
      {
        "slug": "tpm3",
        "symbol": "TPM3",
        "hgnc": "HGNC:12012",
        "name": "tropomyosin 3",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tpm3"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "dmpk",
        "symbol": "DMPK",
        "hgnc": "HGNC:2933",
        "name": "DM1 protein kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmpk"
      },
      {
        "slug": "gle1",
        "symbol": "GLE1",
        "hgnc": "HGNC:4315",
        "name": "GLE1 RNA export mediator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gle1"
      },
      {
        "slug": "slc52a3",
        "symbol": "SLC52A3",
        "hgnc": "HGNC:16187",
        "name": "solute carrier family 52 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc52a3"
      },
      {
        "slug": "sost",
        "symbol": "SOST",
        "hgnc": "HGNC:13771",
        "name": "sclerostin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sost"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      }
    ]
  }
}