Trait

Giant cell hepatitis

Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver.

HPO HP:0200084

Body system: Abnormality of the digestive system Abnormality of the immune system

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library(jsonlite)

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page <- fromJSON(url)
page$trait$name

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5 genes linked to Giant cell hepatitis

Changes in these genes cause rare conditions in which Giant cell hepatitis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AMACRalpha-methylacyl-CoA racemase	Always	In 2 conditions
AKR1D1aldo-keto reductase family 1 member D1	Very often (80–99%)	In 1 condition
VPS33BVPS33B late endosome and lysosome associated	Often (30–79%)	In 1 condition
HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	Not recorded	In 1 condition
VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Liver inflammation

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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