Gene
IYD
iodotyrosine deiodinase
- HGNC 21071(opens in a new tab)
- Ensembl gene ENSG00000009765(opens in a new tab)
- NCBI Gene 389434(opens in a new tab)
Summary
- Cytogenetic location
- 6q25.1
- Coordinates
- Chromosome 6: 150,369,012–150,405,969 (GRCh38)
- Exons
- 5 exons across 37 kb
- Protein
- 289 amino acids
- Also known as
- dJ422F24.1, DEHAL1
- Previous symbols
- C6orf71
- MANE Select transcript
- ENST00000344419.8NM_203395.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
Congenital Hypothyroidism
A thyroid hormone deficiency present from birth.
- 2 GenCC submitters rate it definitive or strong
Thyroid Cancer
- Inherited Thyroid Metabolism Disease
An inherited metabolic disease that is has its basis in the disruption of thyroid hormone metabolic process.
- 2 GenCC submitters rate it definitive or strong
- Hypothyroidism
Abnormally low levels of thyroid hormone.
- 2 GenCC submitters rate it definitive or strong
- Thyroid Gland Disorder
A disease involving the thyroid gland.
- 2 GenCC submitters rate it definitive or strong
How IYD is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 8.6 kb of the gene's 37 kb; 870 of those bases code for the protein.
How a genome test reads IYD
10
positions in IYD where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 37 kb of IYD, introns included, not only the 8.6 kb of exons.
Traits linked to IYD
The Human Phenotype Ontology lists these as features of the rare conditions IYD can cause. Each trait's page lists the other genes linked to it.
Abnormality of the endocrine system
- Decreased circulating T4 concentration
- Elevated circulating thyroid-stimulating hormone concentration
- Enlarged thyroid gland in neck
- Thyroid defect in oxidation and organification of iodide
- Underactive thyroid gland from birth
- Increased radioactive iodine uptake
- Positive perchlorate discharge test
- Reduced radioactive iodine uptake
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). IYD gene: iodotyrosine deiodinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/iyd
Dante Labs. IYD gene: iodotyrosine deiodinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/iyd
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