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Trait

Short 4th long bone of foot

Clinical name: Short fourth metatarsal

Short fourth metatarsal bone.

HPO HP:0004689

Summary

Also called
Bilateral fourth metatarsal shortening, Short fourth metatarsus
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

16 genes linked to Short 4th long bone of foot

Changes in these genes cause rare conditions in which Short 4th long bone of foot is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ERI1exoribonuclease 1AlwaysIn 1 condition
HEPHL1hephaestin like 1AlwaysIn 1 condition
ITPR1inositol 1,4,5-trisphosphate receptor type 1AlwaysIn 1 condition
RSPRY1ring finger and SPRY domain containing 1AlwaysIn 2 conditions
PRMT7protein arginine methyltransferase 7Very often (80–99%)In 1 condition
EZH2enhancer of zeste 2 polycomb repressive complex 2 subunitOften (30–79%)In 1 condition
HDAC4histone deacetylase 4Often (30–79%)In 1 condition
LZTFL1leucine zipper transcription factor like 1Often (30–79%)In 1 condition
PIGSphosphatidylinositol glycan anchor biosynthesis class SOften (30–79%)In 1 condition
ZNF407zinc finger protein 407Often (30–79%)In 1 condition
CDC42BPBCDC42 binding protein kinase betaSometimes (5–29%)In 1 condition
TCF4transcription factor 4Sometimes (5–29%)In 1 condition
DCHS1dachsous cadherin-related 1Not recordedIn 1 condition
FAT4FAT atypical cadherin 4Not recordedIn 1 condition
PEX7peroxisomal biogenesis factor 7Not recordedIn 1 condition
PHYHphytanoyl-CoA 2-hydroxylaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the 4th long bone of footShort long bone of foot

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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